Research Scientist, Protein Engineering and Characterization

Research Scientist, Antibody Engineering and Protein Science

Evive Biotech, a subsidiary of Yifan Pharmaceutical, is a commercial stage global biologics company developing a portfolio of novel biological therapies for patients worldwide. We leverage our proprietary technology platforms to advance a series of innovative drug candidates for oncology and inflammatory disorders. Founded in 2004, we have over 200 employees today with operations in the US, Singapore and China.  (https://www.evivebiotech.com/)(https://en.yifanyy.com/ ).

We are seeking a motivated scientist in antibody engineering and protein science for R&D center located in Hayward, CA, and offer exciting career growth and professional development opportunities working with a highly supportive, skilled, and motivated team, with the vision to develop next-generation therapeutics that benefit patients globally in the areas of immune oncology.

Responsibilities:

·       Support research discovery and development by providing protein engineering and analytical expertise to generate novel therapeutics

·       Interpret protein structural models to aid in rational protein design.

·       Optimize therapeutic antibodies through humanization, affinity maturation and manufacturability engineering

·       Independently carry out protein/antibody plasmid construction, expression, purification and characterization (including but not limited to antibodies, multispecifics, cytokines, or fusion proteins as applicable) to support therapeutic molecule screening, in vitro and in vivo studies

·       Present ideas and experimental results in department and project meetings

·       Potential leadership role in project and people management

·       Other duties as mutually agreed upon to make this position a career building experience

Education, Experience and Skill Qualifications:

·       PhD or equivalent in structural biology, biophysics, biochemistry, bioengineering, chemical engineering or relevant discipline with 5 years’ experience, preferably in biotech or biopharmaceutical industry (Exact title commensurate with experience).

·       Proficiency with homology modeling (e.g. MEO, PyMOL, Schrödinger, Chimera, AlphaFold etc.), structure-function analysis, and protein engineering is required.

·       Proficient in all aspects of protein structural biology techniques including DNA construct design (e.g. PCR fragment assembly, site-directed mutagenesis), protein expression, purification, characterization

·       Familiarity with analytical methods for characterizing the biophysical properties of proteins (e.g., SEC-HPLC, DLS, SPR, BLI, etc)

• Experience with antibody engineering, design, and optimization (e.g., Fv reformatting, affinity maturation, humanization, building multi-specifics, sequence liability remediation, biophysical property improvement) preferred.

·       Attention to detail; accurate and timely documentation of data

·       Team player with effective verbal and written communication skills

·       Self-motivated, resourceful, and adaptive with the ability to understand and establish priorities in a dynamic, timeline-driven, startup environment.

Benefits:

·       Competitive compensation package including base salary, annual bonus potential and 401k

·       Competitive benefit package in healthcare, life insurance, and paid time-off.

·       This is a full-time position in Hayward, CA

Evive Biotech is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Evive is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Evive are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Evive will not tolerate discrimination or harassment based on any of these characteristics. Evive encourages applicants of all ages.