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Research Scientist, Protein Engineering and Characterization

Evive Biotech
Hayward, CA Full Time
POSTED ON 1/17/2025
AVAILABLE BEFORE 4/16/2025

Evive Biotech is a global biologics company developing a portfolio of novel biological therapies for patients worldwide. We leverage our proprietary technology platforms to advance a series of innovative drug candidates for oncology and inflammatory disorders. Founded in 2004, we have over 200 employees today with operations in the US, Singapore, and China.

Check all associated application documentation thoroughly before clicking on the apply button at the bottom of this description.

We are seeking a motivated scientist in protein engineering and characterization for our R&D center located in Hayward, CA. This position offers exciting career growth and professional development opportunities while working with a highly supportive, skilled, and motivated team, with the vision to develop next-generation therapeutics that benefit patients globally in the areas of immune oncology.

Key Responsibilities :

Protein Design and Engineering :

  • Use molecular modeling and docking tools to aid in engineering and optimizing lead molecules with desired properties. Apply techniques such as in vitro display technologies (phage, yeast) and site-directed mutagenesis for lead molecule discovery and optimization.
  • Work closely with the discovery biology team to design and construct proteins and protein fusions that meet target specifications and therapeutic needs.

Protein Expression, Purification and Characterization :

  • Construct expression plasmids.
  • Produce, purify, and characterize engineered proteins.
  • Education, Experience and Skill Qualifications :

  • PhD or equivalent in structural biology, biophysics, biochemistry, bioengineering, chemical engineering, or relevant discipline with 5 years of experience.
  • Significant research experience in macromolecular complexes (antibody-antigen, receptor-ligand, protein complex) structure determination. Proficient in all aspects of protein structural biology techniques including DNA construct design, protein expression, purification, characterization, atomic level structure determination, and analysis.
  • Familiarity with analytical methods for characterizing the biophysical properties of proteins (e.g., SEC-HPLC, DLS, SPR, BLI, Mass spec, etc.).
  • Excellent oral and written communication skills demonstrated by first-author publications.
  • Excellent ability to execute on multiple projects simultaneously.
  • Experience with antibody engineering, design, and optimization (e.g., affinity maturation, humanization, building multi-specifics) preferred.
  • Experience with membrane protein characterization preferred.
  • Benefits :

  • Competitive compensation package including base salary, annual bonus potential, and 401k.
  • Competitive benefit package in healthcare, life insurance, and paid time-off.
  • This is a full-time position in Hayward, CA.
  • Evive Biotech is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Evive is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Evive are based on business needs, job requirements, and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Evive will not tolerate discrimination or harassment based on any of these characteristics. Evive encourages applicants of all ages.

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