What are the responsibilities and job description for the Principal Scientist, In Vitro Pharmacology & Biomarkers position at Flagship Pioneering?
Company Overview : Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of SynteinsTM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular scientists who are passionate about driving therapeutic modality innovation in biotechnology.
Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ : MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.
Position Summary : We are looking for a highly motivated, experienced cell biologist and assay developer to join our growing team and lead the in vitro pharmacology and biomarkers efforts. In this role, the successful candidate will be responsible for conceiving, developing and executing the in vitro pharmacology and biomarker plans to support the progression of the Abiologics pipeline. This role includes hands-on work in the lab, as well as a leadership role in representing her / his Function in the project Teams, mentorship of more junior scientists, and potentially line management of a small team. Occasionally, the incumbent may contribute to in vivo and ex-vivo pharmacology activities to progress the projects and the platform. In addition, this role will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company build-out.
Key Responsibilities :
- Design, develop and execute cell-based assays to assess SynteinTM activity, target engagement and mechanism of action to drive discovery programs
- Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas
- Collaborate with the Discovery team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
- Contribute to in vivo and ex-vivo pharmacology activities to progress the projects and the platform
- Collaborate cross-functionally to enable novel methods, assays and screening workflows
- Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles
- Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings
Qualifications :
Equal Employment Opportunity : Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Application Encouragement : At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
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