Research Scientist – Investigative Toxicology and Pharmacokinetics

FMC’s Global Research and Development organization is looking for a highly-motivated individual to work in the Investigative Sciences Group at its Newark, Delaware, research facility. The successful candidate will support the Investigative Toxicology team conducting mammalian and ecotoxicology studies, including physiology-based pharmacokinetic modeling. Working in an interdisciplinary team environment, the successful candidate will form close partnerships with other scientists, communicating investigational results and placing them into context. The successful candidate’s responsibilities may also include fostering the development of associate scientists in this area.

Responsibilities

• Function as a study monitor in the design, execution and interpretation of in vitro and in vivo mammalian toxicology and ecotoxicology studies placed at Contract Research Organizations.
• Execute in-house in vitro and analysis of in vivo animal metabolism studies, perform pharmacokinetic data analyses and physiology-based pharmacokinetic (PBPK) modeling
• Review all experimental data and ensure timely delivery of reports used for decision-making. Interpret and report the results of experimentation using effective communication skills.
• Maintain and expand knowledge of regulatory and compliance requirements.
• Demonstrate leadership qualities that set a high standard for interpersonal interactions, organizational skills, initiative, team spirit, conflict resolution, decision-making and work ethic.
• Able to thrive in an environment where work involves colleagues from multiple disciplines in a matrixed environment.
• Make recommendations for and implement method development projects in area of expertise to help ensure that technical procedures used for testing and research are current and valid.
• Design, recommend, and oversee method development of in-vitro investigative testing methods based on mechanisms of toxicity. These studies will be designed to facilitate early identification of safety/toxicology concerns and offer opportunities to address project challenges through creative scientific research.
• Participate in industry task forces and/or Agency meetings to keep abreast of new developments in the areas of alternatives to animal testing and PBPK modeling.
• Advance FMC core values, e.g., safety, respect, environmental stewardship, and ethics.

Required Education

• A Ph.D. degree in Analytical Chemistry, Biochemistry, Pharmacology, Environmental Toxicology, or a related discipline with >2 years of experience or a M.S./B.S. with >10 years of experience.

Qualifications

• Practical experience of pharmacokinetics, pharmacodynamics, toxicology, and structure activity relationships.
• Strong interpersonal skills including networking ability with the desire to contribute towards team success.
• Excellent oral and written communication skills.

• Excellent project management skills.
• Familiarity with PBPK modeling software such as Gastro Plus, SimCyp and/or WinNonlin or similar software or demonstrated computer skills to quickly learn and evaluate software to modify/troubleshoot existing PBPK tools.

• The candidate should have a track record of reporting research findings through publication and public presentation.
• Familiarity with global pesticide registration guidelines and data requirements is a plus.
• Experience working with radio-labeled and/or BSL 2 materials is a plus.
• Ability to develop new methods and processes in the area of in vitro toxicology and transcriptomics is a plus.