Research Scientist

Position Overview

We are hiring a Research Scientist. The Research Scientist will be responsible for conducting research and development leading to the development of new products and process optimization of the selected existing product to increase the yield in manufacturing. The Research Scientist will also conduct protein purification at manufacturing scale under the direction of a supervisor.

Company Overview

FUJIFILM Irvine Scientific, Inc. is a global leader in the innovation and manufacture of cell culture solutions for Life Science and Medical markets, providing products and services that assist customers in advancing healthcare initiatives. Working across discovery research, cell and gene therapy, reproductive medicine and cytogenetics, as well as the large-scale production of biotherapeutics and vaccines, the Company is trusted by researchers, manufacturers, and clinicians worldwide. For over 50 years, FUJIFILM Irvine Scientific’s Mission has been to empower all who bring medicines and treatments to life with unmatched quality and responsiveness in its products and custom solutions, providing customers with the vital resources needed to enrich human lives through innovative, accessible therapies. The Company’s facilities adhere to both ISO and FDA regulations, with manufacturing facilities that follow cGMP guidelines in the USA, Japan, and the Netherlands, and a media optimization center in China. All sites prioritize strategies that adhere to the FUJIFILM Sustainability Value Plan 2030 for sustainable growth. FUJIFILM Irvine Scientific, Inc. is a subsidiary of FUJIFILM Holdings America Corporation reporting to FUJIFILM Holdings Corporation.

Job Description

Responsibilities

• Lead and drive protein purification process development activities (existing product and new product), with a focus on optimizing yield, purity, and scalability.
• Design and implement robust purification strategies utilizing a range of chromatographic techniques
• Apply in-depth knowledge of downstream processing to ensure seamless transition from lab-scale to production-scale operations
• Supervise and conduct experimental work related to new product development.
• Oversee and mentor Associate scientists, providing guidance on experimental design, data analysis, and troubleshooting
• Perform protein manufacturing following the purification batch record
• Draft SOPs, batch record templates and associated documentation
• Conduct thorough protein characterization and analysis, assist in trouble shooting equipment and experimental problem
• Collaborate closely with cross-functional teams, including quality control and quality assurance to meet project milestones and goals.
• Contribute to development of long-range plans for R&D.
• Learn, maintain and advance expertise in areas relevant to company’s products and strategic goals.
• Present data to the department and project teams
  
  

Required Skills/Education

• Bachelors in a Biological/Chemical Science plus 6 years, Masters with 4 years, or PhD with 1 years in a Biological/Chemical Science, plus relevant work experience with proteins.
• Relevant work experience with proteins and purification techniques are required.
• Expertise in protein purification techniques, including chromatography (e.g., affinity, ion-exchange, size exclusion), Depth-filtration, TFF and protein analysis methods required.
• Experience in purification of proteins from inclusion bodies including optimization of protein renaturation/refolding.
• Broad experience with recombinant protein construct design.
• Broad experience with analytical protein characterization methods, including HPLC, SDS-PAGE, IEF, Nano UV-Vis, Western-blot, MS/MS and TOF mass spec, SEC-MALS.
• Experience with experimental design including DoE methods.
• Experience in protein purification scale-up preferred.
• Preferable expertise on protein formulation development, design buffer formulations to enhance protein solubility, stability, and shelf-life, develop lyophilization protocol with cryoprotectants and lyoprotectants.
• Ability to speak, read and write English proficiently.
• Good oral and written communication skills
  
  

Benefits

• Medical, Dental, Vision
• Life Insurance
• 401k
• Paid Time Off
  
  

EEO Information

Fujifilm is committed to providing equal opportunities in hiring, promotion and advancement, compensation, benefits, and training regardless of nationality, age, gender, sexual orientation or gender identity, race, ethnicity, religion, political creed, ideology, national, or social origin, disability, veteran status, etc.

ADA Information

If you require reasonable accommodation in completing this application, interviewing, completing any pre-employment testing, or otherwise participating in the employee selection process, please direct your inquiries to our HR Department (fisihr@fujifilm.com).