Radiation Science & Molecular Imaging Specialist

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radioconjugate manufacturing facility to meet supply demand for our growing pipeline of RCs.

The Radiation Science and Molecular Imaging Specialist is responsible for executing on imaging-related clinical operations strategies and tasks to deliver successful operational outcomes in collaboration with cross-functional teams (Clinical Development, Clinical Operations, R&D, CMC, etc.). The candidate will have to collaborate closely with the internal study team and the clinical trial sites and their staffs, NRC and Agreement State regulators and other key stakeholders to help advance and optimize Fusion’s clinical programs to deliver the best possible outcomes for patients.

This position will report to the Manager, Radiation Science Molecular Imaging out of the Boston office.

Responsibilities

• Assist in the development of, and adherence to, imaging trial documents (e.g., Image Review Charter, Imaging Manual, Data Transmittal Forms, and Dosimetry Manuals).
• Provide subject matter expertise to internal and external stakeholders in matters of image acquisition, storage, review, and processing.
• Maintain an archive of imaging related data for ongoing and completed trials.
• Collaborate with clinical operations in the oversight, conduct and management of imaging-related aspects of clinical studies in accordance with the clinical protocol, study manuals and plans, and timelines while ensuring quality in accordance with GCP and ICH guidelines.
• Assist with the management of in-house processing of image data and internal dosimetry efforts to support ongoing research and multi-disciplinary department and company initiatives.
• Provide support for clinical data review; assist in generation of clinical research reports and presentations including abstracts, posters, and publications.
• Provide support to clinical site staff and investigators pertaining to preparation, administration, and waste management of imaging and therapeutic radiopharmaceuticals.
• Respond to radiation safety questions and concerns regarding the use of diagnostic and therapeutic radiopharmaceuticals and precautions.
• Have a working knowledge and understanding of modern electronic infrastructures relevant to radiological imaging such as DICOM, PACS, IHE models, image processing and advanced visualization.
  
  

Qualifications

The Radiation Science Molecular Imaging Specialist must hold at least a Bachelor of Science degree with a life science focus from an accredited educational institution and NMTCB/ARRT(N) certification in nuclear medicine or equivalent. Additional training in radiation sciences (NMTCB(RS)) and/or medical physics with an advanced master's qualifications is preferred.

Candidates should have a minimum of 5 years of medical imaging experience in a clinical environment.

• Scientific expertise in SPECT and PET imaging is strongly preferred, including acquisition, reconstruction and uploading of images.
• Training in Good Clinical Practices (GCP), Quality Assurance/Compliance (QA/QC) in a clinical trial setting is preferred.
• Experience with radioactive materials license amendment process with the NRC and Agreement States.
• Familiar with Radiation Safety Officer (RSO) responsibilities.
• Ability to clearly articulate and present the role and impact of molecular imaging on decision making within drug discovery and development.
• Self-motivation and exceptional verbal and written communication skills.
• Ability to multi-task and work effectively in a team or independently on assigned tasks.
  
  

Proficiency in business computer skills and experience with medical imaging workstations, dosimetry software, and/or PACS preferred.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.