Scientist 1/Scientist 2 Synthetic Biology

GeneFab’s mission is to make innovative genetic medicines available for all. Our synthetic biology team is a go-to R&D taskforce forbiotech and pharmaceutical companies across a wide variety ofdisease indications and therapeutic modalities in the cell and gene therapy space. Scientists on our team pairDNA, RNA, and protein engineering with massively parallel screeningto create technologies thatenhance the performance, precision, and safety of cell, gene, and nucleic acid therapies. 

We are looking for a scientist to join our synthetic biology team to design and execute research programs, develop technologies for our external partners,and expand GeneFab’sSynBioplatform. The scientist will collaborate with GeneFab’s bioinformatics team to design and screen genetic elements (such as promoters, RNA elements, or protein coding sequences) for improved function in primary human cells and immortalized cell lines.In addition to technical proficiency, success in this role will require excellent communication skills for training research associates, internal and external presentation, and cross-functional collaboration. The ideal candidate is curious and collaborative, with a record of successfully executing on multiple workflows at a time.  

• Plan and lead execution of synthetic biology projects including participating inbudgeting and resourcing 
• Design, troubleshoot, and optimize new assays and protocols for a variety of cell types to measure expression, function and/or cell phenotypes 
• Train research associates to execute project protocols 
• Design constructs containing synthetic genetic elements 
• Clone libraries of variantsfor high throughput screening 
• Stay up to date on literature relevant to project focus 
• Analyze and record data and provide advice on project future directions 
• Present work internally and externally 
• Work cross-functionally with multiple teams 
• Contribute to project pitches for potential new clients 
• Contribute to GeneFab’s internal research strategy  

• Scientist 1 
• PhD, Master’s or B.S. in Biology, Synthetic Biology, Bioengineering, Biotechnology, Chemical/Biological Engineering, or related field 
• 0-2 (PhD)/5 (Master’s)/7 (B.S.) years of relevant industry experience  
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• Scientist 2 
• PhD, Master’s or B.S. in Biology, Synthetic Biology, Bioengineering, Biotechnology, Chemical/Biological Engineering, or related field 
• 2-5 (PhD)/7 (Master’s)/10 (B.S.) years of relevant industry experience  

• Mammalian cell culture including experience culturing primary human cells and transfecting/transducing multiple types of cells 
• Molecular Biology (experience cloning libraries and NGS prep preferred) 
• Design of DNA constructs containing synthetic genetic elements (promoters, RNA functional elements, and/or protein coding sequences) 
• Mammalian cell assays including multicolor flow cytometry & data analysis via FlowJo, ELISA or Luminex, and qPCR 

• Lentiviral production (transfection, harvest/purification, titering) 

• Expertise in immunology, cell therapy, and/or gene therapy 

• Fluency with GraphPad Prism and Snapgene 

• Skilled at working with external vendors to acquire needed resources 

• High throughput screening and/or directed evolution 

• Skillful communication demonstrated through publications or awards for presentations, posters, or grants 

About GeneFab 

GeneFab is a contract manufacturing and synthetic biology biofoundry focused on cell and gene therapies. GeneFab was formed in 2023 with a vision to combine industry leading expertise in synthetic biology with advanced cGMP capabilities in order to accelerate the development and commercialization of genetic medicines. GeneFab offers its customers an extensive technology platform and know-how that spans early stage product design, technical development, and cGMP compliant production. GeneFab's technology platform includes bioinformatic-guided discovery of cell type promoters, directed evolution of small molecule-regulated gene switches, and the engineering of highly sensitive kill switches for enhanced safety and control of cellular therapies.

We are committed to an inclusive and diverse GeneFab. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse GeneFab team. We welcome people of different backgrounds, experiences, abilities, and perspectives and are an equal opportunity employer.

Salary : $120,000 - $140,000