Senior Scientist I, CryoEM Microscope Automation

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received over $700 millionin funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300 employees.

The Role:

Generate:Biomedicines is seeking a team-oriented scientist-engineer to advance CryoEM microscope automation. As a subject matter expert, you will drive develop ment of innovative solutions for automating our electron microscop es , ensuring seamless integration into our scientific workflows . You will play a pivotal role in optimiz ation of microscope performance, coordinate maintenance activities, and contribute to the efficient delivery of high-quality protein structures. This role offers the opportunity to spearhead our effort to deploy cutting-edge technology and collaborate across computational and experimental teams to transform the use of experimental structure in biomedicine development.

Here's how you will contribute:

You will elevate CryoEM microscope automation by:

• Building upon existing solutions, as well as implementing novel approaches, to achieve more fully autonomous control over advanced electron microscopes
• Integrating microscope image acquisition with lab informatics, data management, and computational pipelines
• Optimizing microscope performance by tracking outcomes and developing tools that enable proactive and real-time response
• Overseeing microscope maintenance activities and service support through close coordination with external vendors, internal lab operations, and our team of scientist-microscopists
• Refining operating procedures, communicating best practices, and sharing expertise by providing individualized training to team members
• Collaborating closely with team members to ensure that accelerated acquisition through automation is optimized for efficient delivery of high-quality protein structures

The Ideal Candidate will have:

• Ph.D in Structural Biology, Computer Science, Engineering, PhD in a scientific field of study and four (4) years of related experience; or Master’s degree in a scientific field of study and ten (10) years of related experience; or Bachelor’s degree in a scientific field of study and twelve (12) years of related experience.
• Strong programming expertise exemplified by successful deployment of software or plugins for automating electron microscopy (e.g., SmartEPU, SerialEM, Leginon, Latitude, SmartScope, or similar)
• Working knowledge of software and algorithms for processing cryoEM images for 3D reconstruction
• Demonstrated practical experience maintaining electron microscope hardware
• Proven ability to communicate effectively and foster strong relationships with all stakeholders including instrument vendor service and product development teams and internal scientific, IT, informatics, and lab operations teams
• Adaptability to juggle multiple responsibilities with changing priorities, dynamically pivoting focus based on timelines, resources, and real-time outcomes for maximal impact

Preferred additional skills:

• Practical understanding of protein structure and biochemistry including methods to address commonly encountered limitations in specimen preparation (e.g. preferred orientation, aggregation, unfolding)
• Experience augmenting scientist-machine interactions through AI and emerging digital tools
• Familiarity with standard packages and recently published software tools for protein modeling and structure validation
• Experience developing software collaboratively within a team environment

Who Will Love This Job:

At Generate you will advance the mission of our world-class C ryoEM facility and be enabled in your work by abundant collaborative opportunities with our integrated team of computational and wet lab scientists and engineers, working to build a platform that will transfo rm development of biomedicines.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The Company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.