What are the responsibilities and job description for the Principal Scientist, Nucleic Acid Molecular Biology position at Generation Bio?
SUMMARY:
Generation Bio is seeking an energetic and motivated Principal Scientist with experience and technical expertise building siRNA-based therapies. The successful candidate will lead design approaches for optimizing siRNA cargo, through both molecular and chemical intervention. As part of this effort, the Principal Scientist will help build the core infrastructure required for iterative design and evaluation of siRNA molecules to drive program and platform development. The position is cross-functional, requiring collaboration with delivery and preclinical teams to develop siRNA cargo that satisfies program needs. The Principal Scientist will conceive and implement novel approaches to address key platform development goals, developing and driving execution of technical plans individually and as part of teams. This position reports to the VP, head of Molecular Biology and will be responsible for building functional expertise and leading cross functional teams.
RESPONSIBILITIES:
- Lead design approaches for optimizing siRNA therapeutic molecules for high potency, selectivity and durability
- Build the core infrastructure required for iterative design and evaluation of siRNA molecules to drive program and platform development
- Collaborate with pre-clinical teams to develop therapeutic molecules based on program needs.
- Lead execution of research individually and as part of function and cross functional teams.
- Present scientific ideas and results effectively to different teams and groups within the organization.
- Accountable for on-time execution of experimental projects to advance our platform.
QUALIFICATIONS:
- PhD in Molecular Biology, Cell Biology, Synthetic biology, Bioengineering, Chemistry, Biochemistry or related discipline.
- Minimum of 6 years of relevant experience, majority in an industry setting.
- Specific experience with platform development of siRNA cargo
- Deep understanding of molecular/ chemical attributes of siRNA molecules and their translation to function in therapeutic context
- Experience with supporting preclinical development of siRNA therapies is desirable
- Capacity for innovative thinking and critical problem solving.
- Excellent communication and interpersonal skills with capacity and proven track record of working cross functionally.
POSITION: Full-Time, Exempt
