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Senior Associate Scientist / Principal Associate Scientist, Quantitative Platform Biology (contract)

Generation Bio
Cambridge, MA Contractor
POSTED ON 3/26/2025
AVAILABLE BEFORE 4/24/2025
Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune diseases. The company is developing novel therapeutics leveraging its T cell selective cell-targeted lipid nanoparticle (ctLNP) to deliver siRNA in vivo, enabling modulation of T cell activity that causes inflammation and auto-reactive tissue destruction. By selectively modulating T cells that drive disease pathology, ctLNP-siRNA therapeutics could potently block target function with sequence-level specificity while sparing the broader immune system. This potent new modality is designed to reach targets that are poorly drugged by other approaches, opening a broad indication space of T cell driven autoimmune diseases.

We are a thriving, collaborative, creative community of 100 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

Delve further. Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/

Summary

Generation Bio is seeking an enthusiastic and collaborative Senior Associate/Principal Associate Scientist to work in the Quantitative Platform Biology department. This role will provide key pharmacokinetic (PK), biodistribution, and pharmacodynamic (PD) data in support of both platform and project development. In vivo PK and biodistribution experience and expertise with RT-qPCR and stem-loop RT-qPCR assays is preferred. Assay development expertise, experience with T cells, LNPs and other bioanalytical techniques (digital PCR, NGS, ELISA, etc.) is desired. The candidate should be someone who enjoys working in a dynamic and cross-functional atmosphere.

Responsibilities

  • Support platform and preclinical development programs with bioanalytical data
  • Contribute to the development of new assays with input from cross-functional stakeholders
  • Design experiments, analyze data and interpret results
  • Summarize work in written reports and oral presentations
  • Maintain accurate and up-to-date laboratory records
  • Demonstrates a positive attitude and is committed to overcoming obstacles to achieve project goals and objectives

Requirements

  • Masters or a bachelor’s degree with a minimum of 2 years of experience in pharmaceutical sciences, molecular and/or cell biology, or related discipline
  • Biotech and/or pharmaceutical industry experience is preferred
  • Ability to multi-task to support multiple projects across platform and work in a matrixed environment
  • Organized, excellent communication skills, collaborative, team player mindset

POSITION: Contract (6 month)

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Job openings at Generation Bio

Generation Bio
Hired Organization Address Cambridge, MA Full Time
SUMMARY: Generation Bio seeks an energetic and highly motivated (Sr) Director to join the preclinical team and lead our ...
Generation Bio
Hired Organization Address Cambridge, MA Full Time
Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune dise...

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