What are the responsibilities and job description for the SENIOR ASSOCIATE SCIENTIST, PROTEIN SCIENCE position at Generation Bio?
Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune diseases. The company is developing novel therapeutics leveraging its T cell selective cell-targeted lipid nanoparticle (ctLNP) to deliver siRNA in vivo, enabling modulation of T cell activity that causes inflammation and auto-reactive tissue destruction. By selectively modulating T cells that drive disease pathology, ctLNP-siRNA therapeutics could potently block target function with sequence-level specificity while sparing the broader immune system. This potent new modality is designed to reach targets that are poorly drugged by other approaches, opening a broad indication space of T cell driven autoimmune diseases.
We are a thriving, collaborative, creative community of 100 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.
Delve further. Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https : / / generationbio.com / careers /
SUMMARY :
Generation Bio seeks an energetic, versatile, and highly motivated Sr. Associate Scientist to join our discovery research group. For this position, the successful candidate will support the development of our cell targeted lipid nanoparticle (ctLNP) delivery platform. The ideal candidate has a background in antibody discovery as well as expertise in HTP in vitro, plate-based assay development. They will also have experience with basic protein expression and characterization. They will work with the broader discovery organization to identify as well as characterize structural and functional properties of antibodies and / or related molecules using diverse techniques. This role will be responsible for helping to interrogate novel cell targeting mechanisms and enabling cell specific uptake of our LNPs. Responsibilities will also include cross-functional research to enable early program development for indications in target cell types.
RESPONSIBILITIES :
- Perform a range of biochemical techniques such as ELISA, Western blotting, SDS-PAGE, and flow cytometry to characterize protein expression and function.
- Perform a range of biophysical techniques such as surface plasmon resonance (SPR), biolayer Interferometry (BLI), size-exclusion chromatography - multiangle light scattering (SEC-MALS), and differential scanning calorimetry (DSC) or fluorimetry (DSF) to characterize protein-ligand interactions and protein stability.
- Assist to analyze and interpret data from biophysical assays to understand binding kinetics, thermodynamics, and binding affinities.
- Assist to troubleshoot and optimize assays as needed to improve sensitivity, specificity, and reproducibility.
- Maintain accurate and up-to-date laboratory records.
- Routinely present updates at group meetings
REQUIREMENTS :
Preferred Experience and Skills :
POSITION : Full-Time, Exempt
EEOC Statement : Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
