Principal Associate Scientist / Scientist, Immunology Discovery Research

Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune diseases. The company is developing novel therapeutics leveraging its T cell selective cell-targeted lipid nanoparticle (ctLNP) to deliver siRNA in vivo, enabling modulation of T cell activity that causes inflammation and auto-reactive tissue destruction. By selectively modulating T cells that drive disease pathology, ctLNP-siRNA therapeutics could potently block target function with sequence-level specificity while sparing the broader immune system. This potent new modality is designed to reach targets that are poorly drugged by other approaches, opening a broad indication space of T cell driven autoimmune diseases.

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SUMMARY:

Generation Bio is seeking an energetic and highly motivated Principal Associate Scientist / Scientist to join the Immunology team within the Discovery Research group. The position will play a key role in evaluating our cell targeted lipid nanoparticle (ctLNP) delivery platform by designing, executing, and analyzing in vitro assays aimed at evaluating ctLNPs interacting with immune cells. The ideal candidate will have a strong background in cell-based assays (such as but not limited to experience isolating and maintaining primary immune cells, T cell activation/differentiation assays, and flow cytometry). Responsibilities will also include cross-functional research to enable early program development.

RESPONSIBILITIES:

• Contribute to the design, optimization and execution of assays to assess ctLNP interactions with primary immune cells
• Generate target validation / proof of concept data packages using siRNA-mediated modulation of T cell targets
• Work with Preclinical Group to screen novel ctLNPs and target biology for new platform technologies
• Perform a range of biochemical techniques such as ELISA, MSD, qPCR and flow cytometry to characterize protein and RNA expression and function
• Design experiments, analyze data and interpret results
• Summarize work in written reports and oral presentations
• Maintain accurate and up-to-date laboratory records

QUALIFICATIONS:

• Experience in the fields of immunology or cell biology (or related)
• MS with a minimum of 3 years or BS with a minimum of 6 years of industry experience
• Demonstrated hands-on experience in primary immune cell assay development and execution is required
• Experience isolating and culturing primary T cells from human and/or mouse is essential
• Experience with T cell assays (such as T cell activation and differentiation) preferred
• Knowledge of flow cytometry and multi-color panel design strongly desired
• Experience with qPCR, western blot techniques, ELISAs, etc. a plus
• Ability to work cross functionally in a dynamic matrixed environment
• Ability to multi-task to support multiple projects across platform discovery organization
• Organized, excellent communication skills, collaborative mindset

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.