What are the responsibilities and job description for the Senior CADD Scientist position at Genesis Therapeutics?
About Genesis
We’re a tight-knit team of proven drug hunters, deep learning researchers, and software engineers united by a common mission — drive AI innovation in biochemistry, discovering and developing groundbreaking therapies for patients suffering from severe disorders.
Join Our Pioneering Computational Team
Genesis Therapeutics is assembling a world-class computational team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking an exceptional Senior CADD Scientist to join our on-site team in San Diego, working directly with medicinal chemists in our lab. This position requires hands-on collaboration with our medicinal chemistry team to prioritize synthesis, enhance potency and properties, and develop testable hypotheses for molecular design. With deep expertise in protein-ligand interactions, structure-based drug design, and computational screening, you will provide impactful insights that accelerate drug development and shape the future of therapeutic discovery.
As an integral member of the team, you will:
Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets.
The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has signed AI-focused platform collaborations with major pharmaceutical companies, including most recently Incyte Corporation (Feb 2025) and Gilead Sciences (Sept 2024).
We raised a $200M series B in August 2023, and have raised over $300M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures.
Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.
We’re a tight-knit team of proven drug hunters, deep learning researchers, and software engineers united by a common mission — drive AI innovation in biochemistry, discovering and developing groundbreaking therapies for patients suffering from severe disorders.
Join Our Pioneering Computational Team
Genesis Therapeutics is assembling a world-class computational team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking an exceptional Senior CADD Scientist to join our on-site team in San Diego, working directly with medicinal chemists in our lab. This position requires hands-on collaboration with our medicinal chemistry team to prioritize synthesis, enhance potency and properties, and develop testable hypotheses for molecular design. With deep expertise in protein-ligand interactions, structure-based drug design, and computational screening, you will provide impactful insights that accelerate drug development and shape the future of therapeutic discovery.
As an integral member of the team, you will:
- Apply CADD techniques to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents
- Utilize industry-standard CADD tools and proprietary AI-powered tools to analyze protein-ligand structures, run molecular dynamics simulations, and identify optimal drug candidates
- Collaborate with medicinal chemists to design molecules, brainstorm approaches, and select the most effective computational methods to solve project-specific challenges
- Act as a cross-team connector, effectively communicating between computational chemistry and medicinal chemistry teams to ensure seamless information flow
- Provide timely and impactful computational analyses to support key decision-making in drug discovery efforts
- Adapt to a fast-paced environment where innovation and quick iteration are encouraged
- PhD in Computational Chemistry, Structural Biology, or a related field
- Deep understanding of protein-ligand binding interactions and structure-based drug design
- Proficiency with one or more industry-standard CADD tools such as MOE, PyMOL, or Schrodinger Suite
- Minimum of 1-2 years of experience as a computational chemist / CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs
- Strong communication and time management skills, with the ability to provide real-time insights rather than only presenting end results
- Competitive Pay
- Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
- Stock Option Eligibility
- 401(k) Plan
- Open PTO Policy
- Paid Company Holidays
- Free lunch and snacks at our offices
Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets.
The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has signed AI-focused platform collaborations with major pharmaceutical companies, including most recently Incyte Corporation (Feb 2025) and Gilead Sciences (Sept 2024).
We raised a $200M series B in August 2023, and have raised over $300M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures.
Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.
