Staff Scientist (Senior Manager), Reagent Manufacturing

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you:

Glyphic is seeking an experienced reagent manufacturing leader who will report to the Chief Operating Officer and anchor a newly formed Reagent Manufacturing team focused on standardizing and scaling-up Glyphic’s production and R&D reagents in support of a commercial launch. This will be a unique opportunity to define and run new manufacturing processes, build out a dedicated lab, and scale-up by 10-100X in a highly controlled environment.

The ideal candidate should have extensive experience in developing and executing production strategies to ensure long-term reagent supply and a proven ability to translate research protocols into a controlled production environment.

The employee will need to be hands-on in designing and running plate-based manufacturing campaigns using automated liquid handling platforms in addition to liter-scale bulk reagent preparation. A successful candidate will need to work effectively with internal stakeholders (R&D, Product Development, Finance, Operations, Quality) and external vendors to meet current supply obligations and enable future roadmaps. Experience in establishing new reagent manufacturing processes from protocol design to instrumentation selection/qualification in a controlled environment is highly desirable.

Responsibilities:

• Perform complex reagent production protocols and comprehensive QC testing

• Track weekly reagent utilization and generate capacity/demand forecasts to ensure stable and reliable supply
• Manage end-to-end inventory system for raw materials and finished reagents
• Order placement and delivery tracking
• Minimum stock levels and order quantities
• Raw material lead times
• Expiration management
• Perform stability studies to determine shelf life and optimal environmental storage conditions
• Work with external vendors to implement long-term sourcing/supply agreements, evaluate alternative suppliers for critical reagents, and perform vendor qualifications
• Drive process optimization initiatives to reduce costs, increase production efficiency, and improve consistency
• Partner with R&D to define reagent specifications and requirements while ensuring that manufacturability, scalability, and cost are considered as part of all new reagent programs.
• Troubleshoot production issues, perform root cause analysis, and drive corrective actions
• Develop and maintain SOPs and BOMs for all Glyphic reagents
• Maintain detailed batch records and ensure quality/regulatory compliance
• Partner with QC to define, validate, and monitor material quality
  
  

Required Competencies:

• BS/MS in Biology, Chemistry, or a related field with a strong foundation in analytical chemistry (PhD preferred)
• 6 years of reagent manufacturing experience with an emphasis on reagents required for protein and/or DNA synthesis & sequencing
• Extensive experience in solution preparation techniques and analytical methodologies
• Experience running reagent quality control testing, stability studies, and comparability programs
• Experience establishing and managing internal reagent manufacturing operations, external supply partnerships, and supply chains in support of new product launches
• Experience with Lean Manufacturing principles and process optimization
• Proven ability to support on-time customer order fulfillment while ensuring product quality requirements
• Strong background in process design, quality statistics, and structured problem-solving methodologies
• Experience with Lean Manufacturing principles and process optimization
• Strong documentation skills, including SOPs, batch records, and inventory management systems
• Preferred experience with DNA synthesis/purification
• Preferred experience with GLP/cGMP and ISO quality standards
• Preferred experience with automated liquid handling instrumentation
  
  

Benefits and Perks:

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities
  
  

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Compensation Range: $167K - $213K