What are the responsibilities and job description for the Principal Scientist / Associate Director, DMPK position at GondolaBio LLC?

Job Description

Description : About GondolaBio

GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation.

About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 20 drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https : / / bridgebio.com

Who You Are

The primary responsibilities of this position are to serve as a DMPK representative on multi-disciplinary drug discovery teams, provide guidance and support to project teams for candidate selection, and further characterize the pharmacokinetic and drug metabolism properties of molecules through early development to IND. This individual will have the opportunity to be exposed to a broad spectrum of therapeutic areas across the portfolio.

Requirements : Responsibilities

Work closely with cross-functional project team members. Participate as a functional representative on discovery / early development project teams
Provide guidance on discovery project teams for candidate selection, develop and drive DMPK strategies for lead optimization, and solve ADME-related issues
Design, coordinate, and interpret in vitro and in vivo DMPK studies
Determine PK parameters for nonclinical studies using Phoenix WinNonlin and assist with the application of modeling approaches (PK, PKPD) to support human PK and dose predictions
Support GLP toxicology studies, review toxicokinetic reports, and monitor regulated bioanalysis
Monitor bioanalytical method development, validation, sample analysis, and review / approve reports
Generate, analyze and present data, both orally and as written reports

No matter your role at BridgeBio, successful team members are :

Patient Champions, who put patients first and uphold strict ethical standards

Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset

Truth Seekers, who are detailed, rational, and humble problem solvers

Individuals Who Inspire Excellence in themselves and those around them

High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule pharmacokinetics and metabolism with at least 3-5 years of relevant industry experience

Strong understanding of DMPK principles and drug development processes

Expertise in drug metabolism is desirable

Hands-on experience using pharmacokinetic data analysis software such as Phoenix WinNonlin

Able to work independently and possess excellent interpersonal skills

Possess effective problem-solving, oral, and written communication skills

What We Offer

Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts

A culture inspired by our values : put patients first, think independently, be radically transparent, every minute counts, and let the science speak

An unyielding commitment to always putting patients first. Learn more about how we do this here

A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science

A place where you own the vision – both for your program and your own career path

A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game

Access to learning and development resources to help you get in the best professional shape of your life

Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)

Flexible PTO

Rapid career advancement for strong performers

Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time

Partnerships with leading institutions

Commitment to Diversity, Equity & Inclusion

At GondolaBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. GondolaBio is a multi-state employer, and this salary range may not reflect positions based in other states.

Compensation Range : $175,000 to $230,000

Salary : $175,000 - $230,000

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Principal Scientist / Associate Director, DMPK

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