What are the responsibilities and job description for the Investigator, Oncology Drug Discovery (Cellular / Molecular Biologist) position at GSK?
Site Name: Cambridge 300 Technology Square, Upper Providence
Posted Date: Jan 29 2025
The Intracellular Targeted Cancer Therapeutics (ITCT) team in GSK’s Oncology Research Unit is seeking a talented, creative, and motivated scientist with a strong background in molecular biology, cell biology and biochemistry.
This lab-based role will support early target discovery, validation and screening efforts for novel oncology programs. You will work within a cross-functional team of chemists, cellular biologists and proteomic/transcriptomic scientists, utilizing a wide array of molecular biology, biochemical, and cellular assays to identify and validate targets for novel drug modalities such as molecular glues, small molecule RNA therapeutics, and novel ADC warheads.
The ideal candidate will have hands-on experience with various biochemical, molecular and cellular assays, exposure to chemical biology approaches, expertise in assay development, and a strong background in cancer biology and novel oncology targets.
Responsibilities:
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or 1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.
Posted Date: Jan 29 2025
The Intracellular Targeted Cancer Therapeutics (ITCT) team in GSK’s Oncology Research Unit is seeking a talented, creative, and motivated scientist with a strong background in molecular biology, cell biology and biochemistry.
This lab-based role will support early target discovery, validation and screening efforts for novel oncology programs. You will work within a cross-functional team of chemists, cellular biologists and proteomic/transcriptomic scientists, utilizing a wide array of molecular biology, biochemical, and cellular assays to identify and validate targets for novel drug modalities such as molecular glues, small molecule RNA therapeutics, and novel ADC warheads.
The ideal candidate will have hands-on experience with various biochemical, molecular and cellular assays, exposure to chemical biology approaches, expertise in assay development, and a strong background in cancer biology and novel oncology targets.
Responsibilities:
- Design, execute, and troubleshoot molecular, cellular, genetic and biochemical assays for ‘support of’ or ‘discovery of’ novel oncology targets and drug modalities
- Perform mechanistic studies as part of target validation and hit validation efforts
- Generate data in a timely manner and maintain detailed experimental records
- Regularly and effectively communicate findings at project team and company meetings
- Collaborate cross-functionally with biology, biochemistry, chemistry and structural biology colleagues at GSK
- Independently identify novel drug modality and new target opportunities
- Work with HTS team to conduct, analyze and follow up on biochemical and cellular screens
- Manage projects at external CROs
- PhD in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, or related life sciences field with 2 years of postdoctoral experience, or non-PhD with 10 years of experience in drug discovery within the pharmaceutical industry
- Experience with standard cellular, molecular or biochemistry assays or experiments
- Experience designing and executing lab experiments
- Solid background in cancer biology and cancer-relevant pathways (both tumor-cell intrinsic and extrinsic), novel oncology targets
- Experience in the field of chemical biology and the use of small molecule agents to address complex biological questions
- Experience culturing, manipulating and characterizing mammalian cells: cell culture, viral transduction, CRISPR/Cas9 gene editing, viability and mechanistic assays
- Experience investigating protein:protein interactions
- Hands-on experience with cellular and phenotypic screens (genetic or pharmacological), hit finding and validation
- Knowledge of molecular glues, small molecule RNA therapeutics or other non-traditional drug modalities
- Experience with large-scale data interpretation and visualization
- Strong problem-solving skills with sound technically driven decision-making ability
- Effective written and verbal communication skills as well as interpersonal skills
- A creative team player with capacity to be effective in a dynamic company environment
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or 1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.
