What are the responsibilities and job description for the Principal Scientist, Early In-Process Analytics position at GSK?
Principal Scientist – Early In-Process Analytics
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Technical Research and Development is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.
We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we have invested in growing our Research and Development space in Cambridge. As such, we are creating a new hub for mRNA-based vaccine discovery and recombinant protein vaccine early development in Cambridge. We will bring together talent and expertise, building upon our long history of vaccine development, to create globally leading capabilities and cutting-edge technologies for vaccine development, adding to our robust portfolio targeting infectious diseases at every stage of life. Our new laboratories will be focused on the development of state-of-the-art methods to support deep product understanding, process and product development, and bringing cutting edge scientific methodologies to characterize new mRNA and CHO protein-based vaccines.
The In Process Analytics team within the Cambridge-based hub is looking for an Principal Scientist with strong expertise in sequencing technologies to support both the MET and NAV CoE teams. The role of Principal Scientist is expected to develop methods and provide leadership in building the current analytical platform for process intermediates, next-generation cell line development and early stage mRNA platform development to move vaccines faster to the clinic.
Key Responsibilities:
As a Principal Scientist Early In-Process Analytics, you will be expected to take on the main core responsibilities as listed below:
Basic Qualifications:
#Vx-Cam
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or 1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Technical Research and Development is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.
We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we have invested in growing our Research and Development space in Cambridge. As such, we are creating a new hub for mRNA-based vaccine discovery and recombinant protein vaccine early development in Cambridge. We will bring together talent and expertise, building upon our long history of vaccine development, to create globally leading capabilities and cutting-edge technologies for vaccine development, adding to our robust portfolio targeting infectious diseases at every stage of life. Our new laboratories will be focused on the development of state-of-the-art methods to support deep product understanding, process and product development, and bringing cutting edge scientific methodologies to characterize new mRNA and CHO protein-based vaccines.
The In Process Analytics team within the Cambridge-based hub is looking for an Principal Scientist with strong expertise in sequencing technologies to support both the MET and NAV CoE teams. The role of Principal Scientist is expected to develop methods and provide leadership in building the current analytical platform for process intermediates, next-generation cell line development and early stage mRNA platform development to move vaccines faster to the clinic.
Key Responsibilities:
As a Principal Scientist Early In-Process Analytics, you will be expected to take on the main core responsibilities as listed below:
- Design, develop and implement in-process analytical methods to interrogate sequence fidelity in support of both cell line development and mRNA transcript analysis;
- Serve as technical lead and subject matter expert on analytical methodologies for process intermediate results in a matrixed environment;
- Provide analytical development support and training to others within the Nucleic Acid Vaccines (NAV) and Mammalian Expression Technologies (MET) Centers of Excellence (CoEs);
- Collaborate with pre-clinical and analytical research and development teams to help drive innovation in analytical technologies, in support of project timeline deliverables and CMC submissions.
Basic Qualifications:
- Ph.D in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 3 years relevant experience; MS in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 6 year relevant experience; BS in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 9 year relevant experience;
- 2 years of experience leading the design, development and implementation of traditional and state-of-art sequencing methods for a variety of species (mRNA, plasmid DNA, whole cell genome) utilizing PacBio, Oxford Nanopore, MiSeq and related instruments and technologies;
- 1 year of experience designing and implementing state-of-art molecular analytics utilizing quantitative and digital PCR methods for gene detection/verification, genome quantitation and impurity assessments.
- A thorough understanding of biopharma vaccine development processes, with demonstrated ability to communicate across large, cross-functional teams to help propel projects forward;
- Extensive experience with Quality by Design, having developed fit-for-purpose, high throughput, in process analytics to support cell line development and cell line engineering;
- Experience with advanced genomics techniques to monitor insertions, deletions, mutations and other sequence variations in single cell genomes, plasmid DNA, and mRNA transcripts;
- Experience with residual impurity assay development for mRNA and protein drug substances;
- Advanced understanding of bioinformatic methods to deconvolute and condense NGS data for rapid data transfer and results reporting;
- Familiarity with sequence-dependent methods to interrogate the structure of mRNA and/or detect the presence of double-stranded RNA species;
- Experience setting up and running automated liquid handling systems for high throughput sample preparation;
- Experience in preparing clear, well-written protocols for ease of execution across multiple sites;
- Critical thinking ability with a focus on problem-solving to make rational decisions based on effective and accurate data interpretations;
- Positive, open and can-do mindset;
- Fluency in English.
#Vx-Cam
Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or 1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/
