What are the responsibilities and job description for the Scientist II/Senior Scientist, Process Chemistry position at Immunome, Inc.?
Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, IM-1021, a ROR1 ADC with an active IND, and IM-3050, a FAP-targeted radioligand, which is the subject of an IND expected to be submitted in the first quarter of 2025. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.
Position Overview
Immunome is seeking a skilled and motivated Process Chemist with expertise in linker-payload synthesis to join our team. In this role, you will be responsible for overseeing the chemistry and technical aspects of linker-payload production, working closely with Contract Development and Manufacturing Organizations (CDMOs) to ensure the successful execution of synthetic processes. You will also play a pivotal role in process optimization, route development, and ensuring the efficient scale-up of synthesis methods. As part of your duties, you will be expected to travel up to 20% of the time for on-site meetings with CDMOs and other stakeholders.
Responsibilities
$146,562 - $161,845 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, IM-1021, a ROR1 ADC with an active IND, and IM-3050, a FAP-targeted radioligand, which is the subject of an IND expected to be submitted in the first quarter of 2025. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.
Position Overview
Immunome is seeking a skilled and motivated Process Chemist with expertise in linker-payload synthesis to join our team. In this role, you will be responsible for overseeing the chemistry and technical aspects of linker-payload production, working closely with Contract Development and Manufacturing Organizations (CDMOs) to ensure the successful execution of synthetic processes. You will also play a pivotal role in process optimization, route development, and ensuring the efficient scale-up of synthesis methods. As part of your duties, you will be expected to travel up to 20% of the time for on-site meetings with CDMOs and other stakeholders.
Responsibilities
- CDMO Oversight: Manage and provide technical direction for external partners (CDMOs) engaged in linker-payload synthesis. Ensure quality, compliance, and efficient production schedules.
- Process Improvement: Evaluate, optimize, and develop new synthetic routes for linker-payload conjugation to improve scalability, yield, and overall process efficiency.
- Technical Expertise: Provide in-depth scientific and technical expertise in the synthesis of linker-payloads. Address challenges related to process chemistry and collaborate with other teams to resolve technical issues. Comfortable acting as Person in Plant as well as operating in a highly potent laboratory environment.
- Documentation & Compliance: Prepare and review documentation related to process development, scale-up, and validation. Ensure compliance with Good Manufacturing Practices (GMP) and other regulatory requirements.
- Collaboration with Cross-Functional Teams: Work closely with research, analytical, and regulatory teams to ensure smooth project transitions from R&D to GMP manufacturing.
- Travel & Vendor Management: Support travel to external manufacturing sites (up to 20%) to ensure smooth coordination, troubleshoot issues, and assess the progress of manufacturing activities.
- Training & Mentorship: Mentor junior chemists and contribute to the development of team knowledge and best practices in linker-payload synthesis
- Travel: Up to 20%
- Education: Ph.D. or M.S. in Chemistry, Chemical Engineering, or a related field.
- Experience: A minimum of 3–5 years of experience in process chemistry, specifically in the development and synthesis of linker-payloads for antibody-drug conjugates (ADCs).
- Technical Skills: Strong background in organic synthesis, route optimization, and scale-up processes. Demonstrated work experience with chemical reactions involved in linker-payload conjugation and purification is required.
- Regulatory Knowledge: Experience with GMP and regulatory requirements for pharmaceutical and biotech manufacturing.
- Project Management: Demonstrated ability to collaborate with external partners (CDMOs) and oversee complex projects, ensuring timelines, quality standards, and cost-effectiveness are met.
- Communication Skills: Strong written and verbal communication skills with the ability to interact effectively with internal teams, vendors, and other stakeholders.
$146,562 - $161,845 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Salary : $146,562 - $161,845
