SCIENTIST, IN VIVO PHARMACOLOGY

Incendia Therapeutics is a precision oncology company dedicated to reprogramming the tumor microenvironment with the express intent of bringing recalcitrant cancers into submission. We recognize that cancer cells create a hostile microenvironment to privilege their own survival at the expense of the host tissue. Incendia’s approach is to attack the structural and biochemical underpinnings of the tumor microenvironment to enable host immune cells and therapeutics to reach the tumor.

Our mission is to serve cancer patients who are the most in need of novel therapeutics. Everything we do is guided by caring for and doing the right thing for those patients. The Company’s most advanced clinical program is a clinical trial evaluating safety and potential efficacy of PRTH-101 in patients with advanced solid tumors (NCT05753722).

Visit www.incendiatx.com to learn more.

LOCATION

Cambridge, MA

Description

Incendia Therapeutics is seeking a self-motivated individual who desires to have a direct impact on the

science within our early stage, fast-paced, and dynamic biotech team. The candidate will have well-documented scientific expertise in molecular and cellular tumor biology and an abiding interest in drug discovery.

Responsibilities

This scientist will lead the preclinical in vivo pharmacology efforts across Incendia’s drug discovery pipeline, develop and implement project-specific scientific strategies, investigate efficacy and PK/PD relationships of lead compounds, perform detailed mechanism of action studies internally and with external partners, and ensure completion of activities according to project timelines.

Here's What You'll Do:

• Develop preclinical in vivo pharmacology strategies for Incendia’s oncology drug discovery efforts
• Design and execute in vivo studies in syngeneic mouse tumor models to determine antitumor efficacy, pharmacodynamic effects, and pharmacokinetics of drug candidates
• Apply cutting-edge methods to uncover novel insights into target biology at the cancer cell/stromal cell interface and characterize mechanisms of tumor immune exclusion
• Closely collaborate with in vitro biology team and translational group to support MOA research and biomarker efforts
• Analyze, interpret, and document study results; contribute to regulatory and IP filings as needed
• When appropriate, publish high-quality research relevant to the mission of Incendia
  
  

Requirements & Qualifications

This role is highly collaborative, closely works with the in vitro biology team and translational team, supports regulatory and IP functions, and has the opportunity to be part of the decision making within the discovery and clinical teams. The position will report directly to the Associate Director.

Qualifications include:

• PhD and a minimum of 2-5 years of post-graduate experience in preclinical pharmacology, of which at least 2 years in the biopharmaceutical industry, preferably with hands on experience in preclinical mouse tumor models
• Excellent knowledge of human and mouse tumor models in oncology and immune-oncology, and methods to characterize antitumor responses, with emphasis on immune cell characterization, signaling, and stromal biology
• Expertise in designing and executing pharmacology studies to determine drug antitumor effects and identify pharmacologically active doses in PK/PD studies
• Experience in downstream analytical methods, including TIL profiling, IHC/IF, RNAseq, and analysis of drug PK and serum biomarkers by ELISA or MSD
• Direct experience interacting with and/or managing CROs is preferred
• Outstanding collaborative skills, with the ability to rapidly adapt research plans to deliver data in support of internal needs and project timelines
• Independent, self-motivated, and innovative with the ability to excel in a goal-oriented, nimble, and fast-moving team environment
• Effective communicator of data and results to biologists, clinicians, and business partners
  
  

Benefits

• Competitive salary and benefits package
• Opportunity for professional development and career advancement
• A supportive and innovative work environment
• Access to cutting-edge technology and research tools
  
  

At Incendia we strive to build a diverse and equitable workplace

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Powered by JazzHR

29YJIIgoS5