What are the responsibilities and job description for the Principal/Sr. Principal Investigator, AI Driven Early Discovery Chemistry position at Incyte Corporation?
Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.
The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.
Job Summary (Primary function)
Principal/Sr. Principal Investigator, AI driven Early Discovery Chemistry designs and synthesizes novel compounds that meet nomination criteria.
Essential Functions of the Job (Key responsibilities)
- Designs novel core structures/key structural elements for a new project based on HTS leads or published literature compounds.
- Coordinates efforts with CROs for the acquisition and/or synthesis of compounds to advance early discovery programs.
- Drives research projects, demonstrates the ability to formulate hypothesis based on experimental SAR data, proposes strategies and designs novel molecular targets to solve key medicinal chemistry issues related to potency, selectivity and ADME properties.
- Analyze FTO search report and provide suitable data for patent applications (including a well-documented laboratory notebook).
- Meets inventorship criteria as co-inventor on multiple patent applications.
- Present research results clearly to the department, other disciplines and at outside scientific conference.
- Design/conduct organic chemistry experiments to develop and optimize the synthesis of novel compounds.
Qualifications (Minimal acceptable level of education, work experience, and competency)
- Ph.D. in Organic Chemistry or equivalent experience.
- 3 years of related medicinal chemistry experience.
- Understands basic patent law.
- Successful track record of significant contributions to the understanding of the structure activity relationships and ADME data for multiple discovery programs that lead to the identification of clinical candidate(s).
- Life-long learner: leverage extensive use of the literature to increase knowledge base in all aspects of medicinal and organic chemistry.
- Follow the safety rules and maintains a safe working environment.
- Team player: able to work with others in their group, department and company towards the common goal of inventing novel medicines and positively influences the culture of the group.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
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