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Drug Discovery Lead (Senior Director) – GI2 Drug Discovery Unit

Initial Therapeutics, Inc.
Boston, MA Full Time
POSTED ON 2/20/2025
AVAILABLE BEFORE 5/16/2025

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Job Description

Objective / Purpose :

The Gastrointestinal and Inflammation Drug Discovery Unit (GI2 DDU) is seeking an experienced leader and drug hunter to serve as a Senior Director and program leader. This individual will have broad drug discovery expertise, with a proven track record of leading discovery stage programs from project inception to candidate selection and IND. It is expected that the Drug Discovery Lead will lead high priority, top tier GI programs, working closely with our global functional leads to deliver high quality candidate molecules, in addition to mentoring and managing a group of research project leaders with the primary purpose of advancing first and best-in-class assets into the clinic. The candidate will be a recognized leader, have extensive experience of early-stage drug discovery, ideally across modalities, and be accountable for influencing and driving the strategic advancement of our Research portfolio.

Accountabilities :

  • Engage, inspire and lead multidisciplinary project teams to the delivery of high-quality candidate molecules (SMOL or biologics), from project start to IND.
  • Develop, define and execute on project strategy to drive program inflections and navigate critical G / NG decision points.
  • Expertly communicate project status to senior leadership and key stakeholders at all levels.
  • Ensure efficient and optimized use of resources, including management of CRO’s and external partners.
  • Make strategic decisions in consultation with key senior leaders to advance research projects from target selection to clinical entry.
  • Work effectively with partners in the TAU (Therapeutic Area Unit) to develop early clinical development plans and ensure smooth transition of novel molecules through IND enabling activities to clinical entry.
  • Identify and apply state of the art technology and emerging AI / ML driven methodology, where appropriate, to accelerate programs.
  • Serve as a key scientific leader and broadly influence strategic decision both in the DDU and across functions.
  • Engage partners in Business Development as a SME to assess external innovation and support diligence efforts.
  • Mentor and direct a high performing team with a focus on program delivery and developing talented project leaders.
  • Stay abreast of the latest advancements in drug discovery, emerging technologies, and industry trends, and apply this knowledge to enhance drug discovery strategies.
  • Maintain accountability for the development of organizational culture and capabilities : fostering a culture of innovation and scientific excellence within the DDU, promoting collaboration, knowledge sharing, and continuous learning.

Education & Competencies (Technical and Behavioral) :

  • PhD with 15 years’ industry experience or equivalent (MS with 21 years’ experience, or BS with 23 years’ experience).
  • Proven track record of leading multidisciplinary project teams to candidate selection and IND.
  • Experience of working with multiple modalities ideally including small molecules and / or biologics.
  • Highly effective leadership, people management, communication skills, and a team builder management style are essential.
  • Cross-cultural understanding to utilize and develop diverse talent, and a demonstrated ability to manage matrix teams to maximize organizational productivity.
  • Experience in all stages of drug discovery and development.
  • Experience in making recommendations to senior leadership and managing stakeholders across an organization.
  • Keen understanding of modern drug discovery methods and the external innovation landscape, including evolving AI / ML approaches.
  • Experience working with external collaborators and CRO’s.
  • Takeda's high-engagement and ONE Research DEI culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture in all ways of working.
  • This position is currently classified as Hybrid by Takeda’s Hybrid and Remote Work policy.

    Takeda Compensation and Benefits Summary

    We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

    For Location : Boston, MA

    U.S. Base Salary Range :

    205,100.00 - $322,300.00

    The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and / or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

    U.S. based employees may be eligible for short-term and / or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

    EEO Statement

    Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

    Locations : Boston, MA

    Worker Type : Employee

    Worker Sub-Type : Regular

    Time Type : Full time

    Job Exempt : Yes

    It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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    Salary : $205,100 - $322,300

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