Demo

Principal Scientist, Research

Initial Therapeutics, Inc.
Waltham, MA Full Time
POSTED ON 3/8/2025
AVAILABLE BEFORE 6/7/2025

Company :

Visterra is a clinical stage biotechnology company committed to developing innovative antibody-based therapies for the treatment of patients with kidney diseases and other hard-to-treat diseases. Our proprietary technology platform enables the design and engineering of precision antibody-based product candidates that specifically bind to, and modulate, key disease targets. Applying this technology to disease targets that are not adequately addressed by traditional therapeutic approaches, we are developing a robust pipeline of novel therapies for patients with unmet needs.

Visterra is a wholly owned subsidiary of Otsuka America, Inc., which is a U.S. holding company and a wholly owned subsidiary of Otsuka Pharmaceutical Co., Ltd. of Japan. Visterra has approximately 125 employees and is located in Waltham, Massachusetts.

Summary :

Visterra, Inc., is searching for a highly experienced Principal Scientist with a background in design and engineering of biologics. The ideal candidate will have a proven track record of success in discovering and developing antibody-based therapies. This individual will contribute to multiple ongoing research programs, lead new antibody discovery programs, and support the development of novel delivery technologies. The successful candidate will be a collaborative team player, effective manager, critical thinker, and clear communicator. The ideal candidate should have an advanced degree in immunology, biology, biochemistry or a related field and a minimum of five years (post-graduate) of research experience in a biotech or pharmaceutical setting.

This is a full-time position located at Visterra’s offices in Waltham, MA. At Visterra we are making a positive impact on people’s lives through better medicine with a team that champions innovation, teamwork, and perseverance.

Key duties and responsibilities :

  • Lead the discovery and engineering of novel biologics in the fields of autoimmunity, neurology, or nephrology.
  • Evaluate novel technologies in antibody discovery and molecular biology to enhance and streamline discovery workflows.
  • Lead a discovery program from target identification through candidate nomination stages.
  • Design and lead execution of experiments involving antibody libraries, antibody engineering, and antigen characterization.
  • Independently analyze scientific results, troubleshoot methods and conceive creative solutions and workflows to address challenges.
  • Document, analyze and interpret data for internal decision making, publications, presentations, patents and regulatory filings.
  • Work closely with key opinion leaders to advance Visterra’s research interests and development of therapeutics.
  • Manage activities at contract research organizations (CROs).
  • Effectively communicate research results and program strategies internally and externally, including presentations at scientific forums.
  • Maintain expertise by actively participating in conferences and staying current with relevant literature.
  • Includes management of direct reports.

Minimum Qualifications :

  • A Ph.D. or equivalent advanced degree in immunology, biology, biochemistry, or related field and a minimum of five years (post-graduate) of laboratory-based research in industry.
  • Strong foundation in understanding of antibody structure and function, roles in immune regulation, and therapeutic applications.
  • Track record of completing protein engineering projects.
  • Experience conducting original research in cell biology, immunology, target discovery, or therapeutic mechanism of action.
  • Ability to design, develop and execute antibody discovery campaigns.
  • Experience in the screening and characterization of protein-based therapeutics using in vitro and / or cell-based assays.
  • Strong data analysis skills and solid written and oral scientific communication and documentation skills.
  • Track record of managing a team of scientists and research associates.
  • Detail-oriented, organized, team-oriented, enthusiastic, and flexible with effective communication skills.
  • Management responsibilities : This position includes supervisory responsibilities.

    Travel : Possible travel to local and national conferences.

    Visterra provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

    J-18808-Ljbffr

    If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
    Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

    What is the career path for a Principal Scientist, Research?

    Sign up to receive alerts about other jobs on the Principal Scientist, Research career path by checking the boxes next to the positions that interest you.
    Income Estimation: 
    $153,902 - $198,246
    Income Estimation: 
    $230,164 - $328,616
    Income Estimation: 
    $130,030 - $173,363
    Income Estimation: 
    $194,895 - $259,743
    Income Estimation: 
    $192,057 - $260,440
    Income Estimation: 
    $249,515 - $311,938
    Income Estimation: 
    $155,477 - $213,492
    Income Estimation: 
    $151,423 - $191,781
    Income Estimation: 
    $224,177 - $300,651
    Income Estimation: 
    $213,290 - $266,052
    Income Estimation: 
    $225,010 - $318,974
    Income Estimation: 
    $182,205 - $244,055
    Income Estimation: 
    $125,958 - $157,570
    Income Estimation: 
    $120,989 - $162,093
    Income Estimation: 
    $74,806 - $91,633
    Income Estimation: 
    $71,928 - $87,026
    Income Estimation: 
    $145,337 - $174,569
    Income Estimation: 
    $102,775 - $137,396
    Income Estimation: 
    $153,127 - $203,425
    Income Estimation: 
    $139,626 - $193,276
    Income Estimation: 
    $164,650 - $211,440
    Income Estimation: 
    $130,030 - $173,363
    View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

    Job openings at Initial Therapeutics, Inc.

    Initial Therapeutics, Inc.
    Hired Organization Address Boston, MA Full Time
    The Organization What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming ...
    Initial Therapeutics, Inc.
    Hired Organization Address San Diego, CA Full Time
    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare lea...
    Initial Therapeutics, Inc.
    Hired Organization Address San Francisco, CA Full Time
    Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercializ...
    Initial Therapeutics, Inc.
    Hired Organization Address Boston, MA Full Time
    By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that t...

    Not the job you're looking for? Here are some other Principal Scientist, Research jobs in the Waltham, MA area that may be a better fit.

    Research Associate, Researcher I, Researcher II, or Researcher III

    The First Church of Christ, Scientist, Boston, MA

    Research Associate, Researcher I, Researcher II, or Researcher III - New

    The First Church of Christ, Scientist, Boston, MA

    AI Assistant is available now!

    Feel free to start your new journey!