Demo

Scientist, Antigen Engineering & Production

Institute for Protein Innovation
Boston, MA Full Time
POSTED ON 1/26/2025
AVAILABLE BEFORE 2/23/2025
The Institute for Protein Innovation (IPI)is a nonprofit research organization advancing protein science to accelerate research and improve human health. Founded in 2017 and located in Boston’s Longwood Medical Area, the Institute’s three-pronged strategy is to build protein tools, conduct related internal research and develop educational programs for the protein science and biological research communities.

With a significant endowment, IPI uniquely combines the freedom of academia with the high throughput and scale of industry to take on transformative projects. IPI has built a robust platform for discovering, developing, and distributing synthetic antibodies and other protein tools to share with the biomedical community. The Institute's deep protein expertise, collaborative spirit and research tools are powering new biomedical and therapeutic discoveries with a growing community of researchers at Harvard Medical School, Boston Children's Hospital and other institutions across Greater Boston and beyond.

Overview

We are seeking a highly skilled and motivated Scientist to join our Antigen Engineering & Production team. The successful candidate will play a key role in the production and characterization of proteins, with a focus on advancing our capabilities in multipass membrane protein engineering.

Key Responsibilities

Protein Expression:

  • Develop and optimize expression systems for the production of proteins in mammalian cells, insect cells, bacteria, yeast, and other systems.
  • Design and execute expression experiments for a wide range of protein targets, including complex multipass membrane proteins.


Protein Purification:

  • Perform and optimize purification strategies using techniques such as affinity chromatography, ion exchange chromatography, size exclusion chromatography (SEC), and other relevant methods.
  • Troubleshoot and resolve challenges related to protein purity, yield, and stability.


Protein Analysis:

  • Conduct thorough protein characterization using analytical techniques including SEC, Dynamic Light Scattering (DLS), Static Light Scattering (SLS), SDS-PAGE, native PAGE, and other relevant methods.
  • Analyze and interpret data to ensure the quality and integrity of protein samples.


Membrane Protein Expertise:

  • Contribute to efforts in the production and stabilization of multipass membrane proteins.
  • Utilize technologies such as Virus-Like Particles (VLPs), Styrene Maleic Acid Lipid Particles (SMALPs), and nanodiscs to enhance membrane protein solubility and functionality.


Collaboration & Communication:

  • Collaborate with cross-functional teams to advance project goals and timelines.
  • Prepare and present detailed reports, protocols, and data summaries to stakeholders.


Qualifications:

  • Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or a related field with relevant postdoctoral or industry experience;
  • Proven experience in the expression of proteins in various systems, including mammalian cells, bacteria, and yeast.
  • Expertise in protein purification techniques, including affinity chromatography, ion exchange, and size exclusion chromatography.
  • Strong background in protein analytical techniques, such as SEC, DLS, SLS, SDS-PAGE, and native PAGE.
  • Hands-on experience with multipass membrane proteins and related technologies such as VLPs, SMALPs, and nanodiscs is highly preferred.
  • Experience working with complex protein systems or high-throughput protein production pipelines.
  • Familiarity with structural biology techniques and applications.
  • Excellent problem-solving skills and the ability to work independently as well as in a team environment.
  • Strong written and verbal communication skills with the ability to convey complex scientific concepts clearly.


IPI provides competitive compensation and an excellent benefits package to support physical, mental and financial health. Highlights of benefits include:

  • 100% employer-paid medical, dental, and vision plans
  • Flexible spending accounts and a healthcare reimbursement account
  • 401(k) plan with generous 6% employer match – immediately 100% vested
  • Generous PTO package
  • Commuter and parking reimbursement
  • Career development opportunities


For more information, visit proteininnovation.org or follow us on social media, @ipiproteins. IPI is an independent 501(c)(3) nonprofit research organization and an equal-opportunity employer. The Institute celebrates diversity and is committed to creating an inclusive environment for all employees. Please be advised that you will be required to provide evidence of your identity and eligibility for employment in the United States. IPI will not guarantee sponsorship of foreign nationals and retains complete discretion regarding providing sponsorship to any prospective or existing employee at time of hire or at any time in the future.

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