Principal Scientist, Immunology

Janux Therapeutics is seeking a highly motivated Principal Scientist with demonstrated skills in the field of cancer immunology and/or immune cell biology. The incumbent will develop and troubleshoot cell-based assays for pre-clinical programs. These studies will aid in better understanding of MoA and in differentiation from competition. This person will mentor or manage more junior members in the immunology team, as well as interact closely with members across functional teams. A successful candidate will have extensive hands-on experience with assay development and troubleshooting,lead the immunology team in laboratory research to ensure timelines are met, inspire and develop team members, and be accountable for meeting deliverables for the Immunology team.

This position is approximately 30-50% hands-on bench work and requires the effective communication and documentation. The ideal applicant will be collaborative and team-oriented, self-motivated, possess excellent communication and organizational skills, and carry a strong commitment to excellence.

• Lead the development and execution of experimental assays for screening of lead candidates and differentiation of pre-clinical programs from competitors.
• Proactively identify and troubleshoot bottlenecks in existing workflows, technical challenges in assays, etc. to streamline processes and improve reproducibility.
• Interact closely with project teams and other colleagues to advance programs. This includes within the immunology team and across research teams (ie. pharmacology and therapeutics discovery) to ensure shared activities are prioritized and deliverables are achieved
• Accurately and efficiently analyze and interpret data. Ensure data quality and data integrity.
• Gather data from multiple studies and sources to present summary of findings. Highlight impact, major conclusions and next steps. Effectively tailors the presentation for intended audience (ie. junior team members, cross functional team members, or leadership).
• Maintain detailed records of studies in electronic lab notebook.
• Translates development activities into new SOPs. Drafts and revises existing protocols, as needed.
• Draft and review study reports for pre-IND and IND enabling studies.
• Help manage and prioritize activities inside and outside of the lab under tight timelines.
• Identify new external vendors and maintain oversight on CROs (ie. Sequencing, custom conjugations, etc.)
• Keep up to date with published literature centered around targets and therapies relevant to Janux programs
• Develop, coach and mentor junior team members.
• Other duties as deemed necessary

• A PhD in a scientific discipline is common with a minimum of 4 years related experience; or postdoc-experience with 2 years relevant industry experience; BS with minimum 12 years; MS with minimum 10 years experience.
• Hands-on experience with development of multi-parameter flow cytometry (10 colors) assays.
• Proficiency in culture of primary human immune cells (ie. PBMCs) is required.
• Proficiency in flow analysis is required (ie. FlowJo, DIVA, FCS Express, CellEngine, or Cytobank).
• Proficiency in excel, PowerPoint and GraphPad Prism is required.
• Excellent oral and written communication skills.
• Ability to influence others with or without direct authority.
• Experience working with external vendors is a plus.
• Effective troubleshooting and problem-solving skills.
• Success in this role requires great attention to detail with the ability to multitask.
• Skills to be an effective team player, strong individual contributor, self-motivated, flexible, and able to handle multiple tasks and deliver high-quality results under tight timelines.
• Strong organizational skills and related diligence with documentation is required.

Job Type: Full-time

Benefits:

·         401K

·         Medical insurance

·         Dental insurance

·         Vision insurance

·         Supplemental disability insurance plans

·         Flexible schedule

·         Life insurance

·         Flexible vacation

·         Sick time

·         Incentive stock option plan

·         Relocation assistance

Schedule:

·         Monday to Friday

Work authorization:

·         United States (Required)

Additional Compensation:

·         Annual targeted bonus X%

Work Location:

·         On site (San Diego, CA)

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.

Salary : $145,000 - $170,000