Manager, Lead Antibody Production

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We are searching for the best talent for Manager, Lead Antibody Production to be in Spring House, PA.

Purpose: Are you a passionate scientist with expertise in protein expression, molecular biology and biochemistry? Are you an empathetic leader who recognizes the contributions of others and brings out the best in people? If so, then Johnson & Johnson Innovative Medicine is recruiting a Manager, for the Lead Antibody Production team within Therapeutics Discovery. Our department is a central piece to our discovery engine, generating our therapeutic candidates, including ground-breaking Multispecific antibodies and antibody drug conjugates. We strive to capitalize on our talents to discover next-generation medicines to help patients in need. The Manager will lead a team of scientists to express complicated proteins, engineer mammalian cells, innovate upstream processes, and deliver creative research solutions to formidable drug discovery challenges.

You will be responsible for:

• Lead and mentor a team that expresses candidate biotherapeutic molecules in stable mammalian cell culture systems.
• As a protein expression expert, interpret complex datasets to identify and mitigate risks as part of our discovery process. Creatively identify drug developability trends by modeling large datasets.
• Identify value-adding innovative protein production capabilities, industry trends, and emerging technologies and work to evaluate these. Lead creative research efforts (e.g. using ‘omics and screens) to push efficiencies and maintain our organizational competitiveness.
• Collaborate across our company’s global functions to discover innovative medicines. Communicate regularly and accurately within the department and with company leadership to drive our decision making.
• Lead drug discovery projects and research initiatives, ensuring alignment with the company’s strategic goals.
• Prepare and present reports, proposals, and primary data to senior management and partners. Coordinate timelines and deliverables with a wide range of partners and stakeholders.
• Foster a culture of continuous improvement, innovation, learning and development.

Qualifications/Requirements

Education:

• Minimum of Ph.D. in molecular biology, biochemistry, cell biology or similar field with a minimum of 4 years of industry experience is required.

Experience and Skills:

• Evidence of people management is required.
• Expertise in molecular biology including cloning approaches, RNA seq, ATAC-seq, ChIP-seq, or CRISPR mutagenesis is highly sought after.
• Recombinant protein expression expertise is required, including hands-on experience with methods like mammalian cell culture (CHO & HEK293), transfection, and bioreactors.
• Practical experience purifying recombinant proteins using Akta systems with affinity chromatography, IEX, HIC, and MMC is preferred.
• Experience with analytical methods such as HPLC, CE-SDS, SDS PAGE, BLI, and proteomic approaches is strongly preferred.
• Expertise with big data modeling and bioinformatics is especially desired.
• Excellent interpersonal skills, both written and verbal, with the ability to convey nuanced information clearly is required.
• Experience working on multiplexed teams is preferred.
• Proficiency with electronic notebooks (ELN), databases and laboratory information management systems (LIMS) is required.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.