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Bioinformatics Analyst III (Remote)

Katalyst Healthcares and Life Sciences
North Chicago, IL Remote Full Time
POSTED ON 2/14/2025
AVAILABLE BEFORE 5/4/2025

Job description :

We are seeking a Bioinformatics Scientist to join our cross-functional team and provide advanced computational biology support to aid genetic-data-driven target discovery for male-pattern baldness. The successful candidate will use integrated approaches involving a variety of 'omics data to test and refine biological hypotheses in coordination with wet-lab and computational colleagues.

Responsibilities :

  • upstream processing of 'omics data (QC, normalization, exploratory data analysis).
  • downstream interrogation of bulk, single-cell, and / or spatial transcriptomic data (e.g., differential gene expression analysis, gene set enrichment analysis, cell type annotation, cell trajectory analysis, cell-cell communication analysis).
  • Additional responsibilities may include analysis of proteomics or other data modalities depending upon project needs.
  • Applicants should be familiar with high-performance computing systems, shell scripting in a Linux environment, and have strong facility with R and / or Python, including relevant bioinformatics packages (e.g., Seurat, edger / lima).
  • Those with experience integrating multi-modal data (e.g., scRNAseq scATACseq, spatial RNAseq spatial proteomics) are especially encouraged to apply.

Requirements :

  • PhD in Bioinformatics, Genetics, Molecular and Cellular Biology, or related field or MS with at least 6 years of experience.
  • single-cell and / or spatial transcriptome QC and analysis (e.g., with Seurat or Scanpy).
  • bulk RNAseq data processing and analysis.
  • facility with R and / or Python for data exploration and statistical analysis.
  • experience with high-performance computing (HPC) and job submission systems.
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