What are the responsibilities and job description for the Scientist - II position at Katalyst?
Job description:
The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development organization. The Biologics CMC Developability team conducts high-throughput screening of physicochemical properties of discovery-stage biologic drug candidates to identify liabilities, helping in the selection of lead candidates for pipeline advancement. We have an exciting opportunity for a motivated scientist to join the client’s Biologics CMC Develop ability team based in Worcester, MA.
Responsibilities:
- Conduct laboratory-based high-throughput screening and analytical, biophysical, and biochemical characterization of biologic drug candidates.
- Perform experiments to screen physicochemical properties of biologic molecules (antibodies, bispecific antibodies, antibody drug conjugates, and genetic medicine modalities) and identify liabilities that may impact drug development.
- Enable automation and high-throughput screening of discovery candidate molecules.
- Execute experimental protocols, collect results, and perform data analysis independently.
- Maintain excellent documentation of work including electronic lab notebook and protocols.
- Prepare and deliver concise scientific presentations of experimental results.
- Oversee maintenance of key laboratory equipment and routine laboratory operations.
- Build strong relationships with other team members and across groups.
- Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.
Requirements:
- BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3 (BS) or 1 years (MS), biopharmaceutical industry experience preferred.
- Hands-on experience in protein biochemical and biophysical characterization.
- Experience with diverse biologic formats desired.
- Detailed knowledge of protein structure, biophysical characterization, and formulation screening.
- Experience in protein biophysical and biochemical characterization techniques, including chromatography (size-exclusion, ion exchange and hydrophobic interaction chromatography), differential scanning calorimetry & fluorimetry, dynamic light scattering, UV-VIS and fluorescence spectroscopy, imaged capillary isoelectric focusing, capillary electrophoresis, particle and viscosity measurements.
- Must be willing and able to learn new technologies as needed.
- Prior experience in high-throughput automation and mass spectrometry would be beneficial.
- Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
- Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables.
- Able to perform data analysis using MS Excel & GraphPad.
- Team player with excellent collaboration and communication skills.
Job Type: Contract
Pay: $37.00 - $40.00 per hour
Work Location: In person
Salary : $37 - $40
