What are the responsibilities and job description for the Senior Research Associate, Small-scale Oligonucleotide Synthesis position at Korro Bio?
Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
Position Summary: Korro Bio is looking for a Research Associate or Senior Research Associate to join our small-scale high-throughput oligo synthesis team. This individual will work at the Cambridge, MA site performing solid-phase synthesis of novel and highly substituted oligonucleotides to support a number of internal programs.
- Solid-phase synthesis of highly substituted oligonucleotides using an automated synthesizer, such as a MerMade 192x.
- Perform cleavage and deprotection of oligonucleotides and determine appropriate C&D parameters based on the chemistry of your samples.
- Desalting and quantification of oligonucleotides.
- Analysis of oligonucleotide samples via direct-inject Mass spectrometry. Identify key impurities and plans to reduce or eliminate them.
- Keep meticulous records of data in the Electronic Lab Notebook.
- Communicate with other team members regarding shared resources, timelines, etc.
- Candidate should have strong chemistry foundation and knowledge of organic chemistry fundamentals.
- 2 years of industry experience.
- Candidate with prior experience of performing solid-phase synthesis, cleavage and deprotection, quantification, and characterization of oligonucleotides is plus, but not required.
- Candidate familiar with the use of automated synthesizers such as MerMade 192 specifically is a plus.
- Familiarity with Microsoft Office Suite and Chemdraw software.
- Excellent communication skills.
Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account, a Company-funded health savings account, and free parking.
