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Scientist II/III, Analytical Development (Mass Spectrometry)

Kriya Therapeutics, Inc.
Durham, NC Full Time
POSTED ON 1/30/2025
AVAILABLE BEFORE 2/28/2025
About Kriya

Kriya is a biopharmaceutical company whose mission is to develop life-changing gene therapies for diseases affecting millions of patients around the world.

We leverage our proprietary computational engine, in-house manufacturing infrastructure, and integrated design platform to engineer technologies and therapeutics with the potential to transform the treatment of a broad universe of diseases of high unmet need, with a focus on metabolic disorders, neurology, and ophthalmology.

We are proud to have been named Triangle Business Journal’s Life Sciences 2024 “Best Private Company to Work For,” recognized by Forbes as one of “America’s Best Startup Employers of 2024,”and honored as one of BioSpace’s “2025 Best Places to Work.”

Who You Are

The Scientist II or III, Analytical Development (Mass Spectrometry) is responsible for establishing and maintaining LC/MS/MS capabilities within Kriya. The scientist utilizes LC/MS/MS capabilities to support AAV capsid characterization and impurity identification as well as bioanalytical method development and analysis.

How You Contribute

  • Assist in the analysis and optimization of LC/MS capabilities for characterization of AAV viral proteins and protein impurities.
  • Develop methods for analysis of bioanalytical samples, and analyze samples by developed methods.
  • Collaborate with process development, formulation development, and bioanalytical teams to define LC/MS analysis needs and draw conclusions from MS data
  • Review, edit, and possibly author technical protocols and reports.
  • Support investigations when necessary to support non-clinical bioanalytical studies.

Education & Experience

What You Bring to the Team

  • Degree in relevant discipline plus relevant working experience in a pharmaceutical/ biotechnology or CRO laboratory setting.
  • Bachelor’s degree with 8 years’ work experience
  • Master’s degree 4 years’ work experience
  • PhD degree or equivalent with 2 years’ work experience

Competencies

  • Experience characterizing proteins and protein impurities using LC/MS and LC/MS/MS is required. Experience analyzing AAV samples by LC/MS and/or LC/MS/MS preferred.
  • Experience developing MS-based methods for bioanalytical analysis is preferred.
  • Experience with Themo Orbitrap mass spectrometers preferred.
  • Understands current analytical methods deployed for AAV or protein stability and characterization.
  • Understands protein degradation pathways and expected degradation profile.
  • Has experience working in a multi-disciplinary team environment.
  • Is highly self-motivated and flexible and operates well in a start-up environment.

Working Conditions

  • Primarily a laboratory setting
  • May involve standing, sitting, and using laboratory equipment for extended periods.
  • Some lifting of equipment or materials may be required.

Discover True Collaborative Teamwork

We have an ambitious set of goals, but our confidence – and our inspiration – stems from our people. From California to North Carolina, our teammates bring a spirit of Collaboration, Leadership, and Innovation to their work every day. We’re always looking for teammates with the drive and energy to help us grow. If you want to be a part of a company with an entrepreneurial culture, a bold vision, and a meaningful purpose, join us.

What We Offer

Medical, Dental and Vision 401(k) with Company Match Short and Long-term Disability Benefits Company Paid Holidays Flexible Time Off Cyber Safety protection EAP Life Insurance Equityand more!

Kriya is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

All job requirements in the job description provided indicate the minimum level of knowledge, skills, and/or abilities deemed necessary to perform the job competently. Job descriptions are an overview of the duties, responsibilities, and requirements of the position. Employees may be required to perform other job-related assignments as requested.

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