Associate Director/Director of In-Vivo CAR-T

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking as part of the Research and Development team based in Philadelphia.

Role Overview

Legend Biotechnology is at the forefront of developing innovative cell-based therapies. We are seeking an experienced and dynamic Director to lead our in vivo CAR-T cell therapy program. If you're passionate about advancing groundbreaking treatments and have a strong background in cellular immunotherapy, this role is for you. This individual will report to the Executive Director in R&D. This position will play a pivotal role in shaping our in vivo CAR-T cell therapy program. You will collaborate with cross-functional teams, including research, development, and manufacturing, to drive the successful translation of preclinical findings into clinical applications. Your expertise will be critical in advancing our mission to improve patient outcomes.

The successful candidate should possess extensive knowledge and research experience in binder screening, virology, molecular biology, in particular virus engineering and in vivo application experience. The candidate has project management experience to move program to clinical such as support US IND. 8 year biotech or pharmaceutical industry experience is preferred.

The candidate needs to demonstrate the ability of delivering scientific results with integrity and meeting timeline, show the value of collaboration and teamwork, and provide strategy, expertise, resources, and guidance in a cross-functional environment.

Key Responsibilities

• Provide strategic direction for in vivo CAR-T cell therapy development. Work with team members and cross-functional teams include research, clinical, and regulatory teams to ensure alignment and successful execution of the program.
• Stay abreast of the latest advancements in cell therapy, especially in vivo CAR-T cell therapy
  
• Lead team to design and execute experiments, document, and interpret scientific results, prepare preclinical data package
• In vivo study design and assay development. NHP study experience is a plus.
• Manage pipeline development to meet different milestone such as IND.
• Can work in lab and manage projects to meet timeline in a fast-paced environment.
• Represent team to update project in cross-functional team meeting and review committee
• Foster a collaborative environment that encourages innovation and excellence.
  

Requirements

• Ph.D. in a relevant scientific discipline (e.g., immunology, cell biology, molecular biology, virology) with a minimum of 8 years of industry experience.

• Proven track record in cellular immunotherapy, particularly in CAR-T cell therapy and gene therapy.

• Experience with in vivo CAR-T and preclinical studies.

• Excellent leadership, communication, team and project management skills.

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.