What are the responsibilities and job description for the Director of In Vivo Pharmacology position at Legend Biotech US?
Company Information
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking Director of In Vivo Pharmacology as part of the Research & Development team based in Piscataway, NJ.
Role Overview
This position will perform preclinical and IND-enabling in vivo pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have knowledge and experience in immunology or immune-oncology and in vivo study with mouse and NHP. The successful candidate will work in a collaborative environment and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.
Key Responsibilities
- Conduct in vivo studies with mice and NHP to assess CAR-T / NK mediated efficacy and toxicity with disease models of tumor or autoimmune disease. This includes designing and implementing in vivo pharmacology studies to support early-stage research programs and late-stage IND-enabling studies
- Interact with and manage CROs for in vivo study related activities
- Interact and collaborate with research teams for in vivo pharmacology and toxicology studies
- Process and analyze tumor and tissues samples from mice and NHP
- Assess safety and tox risks of cell-based drug products
- Analyze, document and report all experiment findings
- Perform additional exploratory and investigational studies with various techniques
Requirements
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Legend Biotech is a proud equal opportunity / affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic / civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
Legend Biotech maintains a drug-free workplace.
