What are the responsibilities and job description for the Scientist Solid Tumor CAR position at Legend Biotech?
Legend Biotech is seeking a Scientist Solid Tumor CAR as part of the Research & Early Development team based in Philadelphia, PA.
Role Overview
This position will join a new interdisciplinary team focusing on the development of Legend’s engineered cell therapy platform for treating solid tumor.
Qualified candidates should have hands on experience working with CAR-T and/or other engineered immune cell types for solid tumor cell therapy discovery.
The ideal candidate should be driven, analytical, thoughtful and creative, who can function both independently and collaboratively in a fast-paced environment.
This position will initially report to Senior Director of Research. Location: Philadelphia.
Key Responsibilities
Legend Biotech maintains a drug-free workplace.
Benefits:
Role Overview
This position will join a new interdisciplinary team focusing on the development of Legend’s engineered cell therapy platform for treating solid tumor.
Qualified candidates should have hands on experience working with CAR-T and/or other engineered immune cell types for solid tumor cell therapy discovery.
The ideal candidate should be driven, analytical, thoughtful and creative, who can function both independently and collaboratively in a fast-paced environment.
This position will initially report to Senior Director of Research. Location: Philadelphia.
Key Responsibilities
- Design and execute CAR-T cell functional assays.
- Design strategies to address target-expression heterogeneity for novel CAR design.
- Develop in vitro assays to assess CAR-T cell bystander killing and antigen-spreading.
- Analyze and interpret data, troubleshooting, present to and engage internal stakeholders
- Stay abreast of the latest advancement of cell therapy in solid tumor. Develop relevant insight in selected disease area.
- Scientist- PhD in Immunology, Immuno-Oncology or related field 0-3 years of post-phD experience.
- Proficiency in conventional immunological techniques such as primary T cell isolation, gene editing/transduction, expansion, ELISA, cell sorting and flow cytometry is required.
- Broad knowledge in T cell antigen presentation, Dendritic cell, Macrophage, monocyte biology and their implications in TME ( eg. Liver, lung and colorectal cancer) is preferred.
- Experience in CAR-T animal models, especially with utilizing in vivo CAR modalities such as engineered lentivirus or LNP/mRNA is a plus.
- Experience in T cell tetramer analysis and clonal-expansion is a plus.
- Experience working with Bispecific T cell engager is a plus.
- Innovation in cell therapy space is preferred as evidenced by publications and patents.
- Language: English
Legend Biotech maintains a drug-free workplace.
Benefits:
- Health Insurance
- Dental Insurance
- Vision Insurance
- Life Insurance
- Matched 401K
- Flexible Spending Account
- Health Savings Account
- AD&D Insurance
- Short-Term Disability
- Long-Term Disability
- Paid Maternity Leave
- Paid Paternity Leave
- Pet Insurance
- Critical Illness Insurance
- Hospital Indemnity Insurance
- Accident Insurance
- Legal Insurance
- Commuter Benefits
- Employee Assistance Program
