Associate Vice President, Investigative ADME, Toxicology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Overview:

The Investigative ADME/Toxicology (Absorption, Distribution, Metabolism, Excretion) and BioAnalytical Research (BAR) group is an organization purpose-built team to ensure we provide stage-appropriate, issue-driven solutions to molecular creation teams that make life better for people. We focus on using cutting edge science to unlock new approaches that can treat people suffering from diseases with poor treatment options. We continually challenge ourselves to deliver molecules that can provide breakthrough efficacy with the highest possible safety margins. We are committed to continually optimizing our mindset, technology and processes to improve our speed of execution. We relentlessly pursue a culture anchored in empowering scientists and teams to innovate and advance projects through deep collaboration and personal accountability.

Position Summary:

The Investigative ADME/Toxicology and BioAnalytical Research team focuses primarily on drug discovery. We have an immediate opening for a seasoned leader for our cross-site Investigative ADME and Toxicology teams. The candidate should have a passion for developing discovery ADME and Toxicology program leads together with mechanistically curious lab-based scientists which deliver reliable results at the pace discovery research demands. The candidate should demonstrate a record for leading groups across multiple sites while maintaining a deep knowledge of current technology to solve assay challenges across modalities. Collaboration with ADME and Toxicology project leaders, lab-based scientists and medicinal chemists is essential. This role requires excellent people skills, a positive attitude, willingness to learn, attention to detail, and the ability to thrive in a fast-paced team environment.

Key Responsibilities:

• Work closely with organizational VP to ensure a cohesive/integrated investigative ADME and Toxicology team within the department focused towards providing strategic oversight and next-level leader mentorship to functional area group leads promoting cross site integration and organizational effectiveness.
• Collaborate with therapeutic areas and molecular creation teams (new Molecular Medicines Discovery (MMD) group, LGM (Lilly Genetics Medicine), and BioTDR (Biotechnology Discovery Research)) to ensure lab-based excellence and innovation across modalities.
• Engage with leadership from the new Lilly Small Molecule Discovery team to ensure program project leader support is stage-oriented with an emphasis on solving challenging problems effectively and efficiently to support program progression and ensuring project learning improve overall performance across a variety of inhibition mechanisms, including but not limited to, enzyme inhibitors, molecular glues, proximity induction, and targeted protein degraders.
• Cultivate a growth mindset within the team and amplify project learnings on key issues improving performance across discovery and development.
• Work with leaders to ensure critical success factors are outlined for teams to ensure delivery of quality medicines and stage-oriented execution of work within the Lilly Research Lab portfolio.
• Champion a range of modern computational techniques including Quantitative Structural Activity Relationship (QSAR) models, homology modeling, molecular dynamics simulations, multivariate analysis, and in silico predictive models to enable SAR triage in draggability and safety questions.
• Demonstrated experience leading a team of program leads where a focus has been on developing performance plans and objectives for staff, while providing mentoring and coaching to staff to facilitate professional development.
• Challenge the organization to actively tackle ambitious goals and bring new technology to increase efficiency and excellence to the group.
• To be adept at communicating team expectations, setting team objectives and helping to craft larger organizational goals.
• Engage with leadership from the new Lilly Small Molecule Discovery team to ensure program project leader support is stage-oriented with an emphasis on solving challenging problems effectively and efficiently to support program progression and ensuring project learning improve overall performance across a variety of inhibition mechanisms, including but not limited to, enzyme inhibitors, molecular glues, proximity induction, and targeted protein degraders.
• Cultivate a growth mindset within the team and amplify project learnings on key issues improving performance across discovery and development.
• Work with leaders to ensure critical success factors are outlined for teams to ensure delivery of quality medicines and stage-oriented execution of work within the Lilly Research Lab portfolio.
• Champion a range of modern computational techniques including Quantitative Structural Activity Relationship (QSAR) models, homology modeling, molecular dynamics simulations, multivariate analysis, and in silico predictive models to enable SAR triage in draggability and safety questions.
• Demonstrated experience leading a team of program leads where a focus has been on developing performance plans and objectives for staff, while providing mentoring and coaching to staff to facilitate professional development.
• Challenge the organization to actively tackle ambitious goals and bring new technology to increase efficiency and excellence to the group.
• To be adept at communicating team expectations, setting team objectives and helping to craft larger organizational goals.

Basic Requirements:

• PhD with minimum of 15 years academic/research/industry exp (may include post-doc experience) or MS with 20 years industry/academic/research experience within the pharmaceutical sector, or a closely related field.
• 6 years of demonstrated experience leading a team of scientists which contribute to or develop, validate, implement and/or approve appropriate analytical or enzymatic assays, methods or enhanced throughput screens used for quantification or structural identification of compounds or biomarkers, to determine pharmacokinetic, drug disposition, and/or safety parameters, and to determine transport or biotransformation properties, in compliance with GLP and/or OECD guidelines where required.
• Ability to create, sustain and model a culture of innovation, collaboration, and dedication.

Additional Information:

• This position will be based at the Indianapolis, IN (preferred) or Louisville, CO or San Fransico, CA site.

Additional Preferences:

• 10 years of leadership experience preferred.
• Ability to create, sustain and model a culture of innovation, collaboration, and dedication.
• In-depth knowledge of hit-to-lead to candidate optimization across ADME and Toxicology disciplines.
• Proven ability to collaborate across disciplines to achieve project goals and timelines.
• Flexible in prioritizing to meet organizational and scientific objectives.
• Ability to work independently and as an integral part of a larger collaborative team
• Highly organized with strong analytical, documentation, time management, and multi-tasking skills.
• Sees personal success as part of team success.
• Self-driven and data-dependent decision maker.
• Anticipates challenges and proactively proposes solutions.
• Adaptive and applies creative problem-solving to meet needs.
• Capable of leading with team empowerment and buy-in.
• Self-driven, hardworking, lab first, data dependent decision maker

Physical Demands/Travel:

• The physical demands of this job are consistent with an office environment, and to a lesser extent, lab environment.
• The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

• This position’s work environment is primarily in an office with a small amount of lab time. The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
• To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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