Biologist – Neurodegeneration

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Eli Lilly and Company seeks a highly motivated scientist to join our Neurodegeneration team. This position is a part of a multidisciplinary team dedicated to discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, ALS, and other related neurodegenerative conditions. The individual will apply cutting-edge histological and imaging techniques to support our expanding neurodegeneration portfolio. A primary focus of this position will be the establishment and utilization of imaging/histological techniques to support therapeutic investigations in multiple pre-clinical animal models.

Key Objectives/Deliverables:

• Perform histological lab techniques including, but not limited to tissue processing, paraffin embedding, tissue sectioning, routine and special tissue staining, imaging and image analysis.
• Establish and execute multiplexed immunohistochemistry (IHC) and in situ hybridization (RNAScope) to evaluate in vivo efficacy of therapeutic agents
• Contribute to development, validation, and performing advanced histological/imaging techniques like spatial transcriptomics, super-resolution microscopy, light sheet microscopy and in vivo two photon imaging
• Assist in troubleshoot technical challenges and provide scientific/technical input to project teams
• Design, execute experiments and perform data analysis
• Communicate results to the project team to drive data-driven decisions
• Provide written and verbal communication of work in lab reports and team meetings
• Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards
• General laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipment
• Ensure compliance with all health and safety regulations
• Report on-site, in the lab, 5 days a week

Basic Requirements:

• Bachelors degree in Neuroscience, biological sciences or related scientific fields
• Academic or industry experience with histologic analysis of animal models

Additional Skills/Preferences:

• Previous experience in neuroscience research is preferred
• Hands-on experience in autostainer (e.g. Leica Bond-RX), slide scanner imaging (e.g. Olympus VS200)
• Knowledge of relevant image analysis software packages: HALO, QuPATH and ImageJ
• Experience in stereotactic surgery and in vivo imaging is a plus
• Hands-on experience in cDNA library preparation for transcriptomics is a plus
• Ability to design, execute and interpret experiments independently
• Excellent communication skills and efficiency in collaborating across functional team
• Strong organization skills, attention to detail, critical thinking, multitasking, desire to learn new techniques and contribute to cutting-edge projects in a fast-paced working environment

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Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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