What are the responsibilities and job description for the Scientific Director – Medicinal Chemistry - Oral Macrocyclic Peptides (Indianapolis, IN) position at Lilly?
Check you match the skill requirements for this role, as well as associated experience, then apply with your CV below.
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
This is a technical leadership position in the Peptide Therapeutics Team within Biotechnology Discovery Research in Indianapolis. The ideal candidate will have the responsibility to identify, optimize, evaluate, and advance to clinical development oral macrocyclic peptides. This individual will be a significant contributor and will lead the Medicinal Chemistry Team as part of a highly integrated and collaborative team effort in this novel peptide modality. Ideal candidate is expected to have demonstrated success in similar roles with proven track record of leading both scientific rationale, planning and execution leading to success in making medicines.
The individual will independently lead projects, supervise scientists, contribute significantly to prioritization of the team objectives, propose strategies and future directions to meet broader portfolio objectives in the oral macrocyclic peptide space, optimally manage resources, and effectively communicate progress to management and governance committees. Also, will interact cross-functionally within Biotechnology Discovery Research, and across including in groups of Discovery Chemistry Research and Technology (DCRT), Therapeutic Area Teams, Drug Disposition, Product Development and Regulatory Affairs.
KEY OBJECTIVES / DELIVERABLES :
- Lead Medicinal Chemistry Group in efforts in oral macrocycle peptides.
- Initiate and lead new oral macrocycle peptides research projects, formulate strategy and execute on the strategy organizing team efforts for deep technical development and to accelerate from target to hit identification and lead optimization towards candidate declaration.
- Implement rational SAR strategies to improve pharmaceutical properties of peptide leads in the oral macrocyclic space. This requires a broad repertoire of skills and knowledge of peptide properties including peptide synthesis and conformational analysis, molecular modeling, computational methods, analytical and physicochemical characterization.
- Therapeutic Area Focus : candidate is expected to exhibit strong problem-solving abilities and be familiar with understanding and resolving issues that lie at the interface of peptide engineering, pharmaceutical developability and formulation, and biology. Prior experience with moving a therapeutic opportunity to proof of principle confirmation in humans is seen as an advantage.
- Leadership : In advancing the optimization of lead therapeutic molecules in the oral macrocyclic peptide space, will be required to lead / co-lead multidisciplinary teams. Accordingly, strong communication and presentation skills in sharing research findings and team plans, and effective teamwork will be required.
- Inspire people to collaborate in inventing great medicines by removing barriers, committing to high quality scientific hypotheses, and accelerating where possible.
- Always keep safety as a top priority, striving toward a proactive safety culture.
- Be an advocate for diversity and inclusion in our recruiting, retaining and developing scientists, with a commitment to coaching and development of scientists.
BASIC REQUIREMENTS :
5 years of experience in a biotechnology / pharmaceutical company.
ADDITIONAL PREFERENCES :
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