What are the responsibilities and job description for the Head of Biotherapeutics (Sr. Director or VP Level) position at Manifold Bio?
Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics.Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.
Position
Manifold Bio is seeking an experienced biotherapeutics expert to join our growing team pursuing our mission of multiplexed, in vivo drug discovery. This role will drive the protein therapeutic workflow at Manifold, from discovery through CMC. The ideal candidate will have extensive protein engineering experience across diverse formats and modalities and deep knowledge of protein production strategies to supply high throughput screening pipelines. You will focus on deploying cutting edge protein engineering technologies to reach best-in-class product profiles in a timely and cost-effective manner. Further, you will engage the rest of the R&D team to integrate your approaches with the unique protein multiplexing technology we've developed at Manifold. You will be a critical part of our transition from a discovery stage to a clinical stage company, bringing ample experience taking molecules through IND, particularly with regard to biologics manufacturing. Together, we'll continue to build a transformational company based on the vision of massively increasing the throughput of testing of protein therapeutic designs to fundamentally change the current paradigm of drug development.
Responsibilities
- Leading internal protein sciences and protein engineering teams
- Own strategy for early stage de-risking and optimization of lead molecules
- Own strategy for developability assessment
- Work with internal and external team members to ensure cost-effective and timely drug manufacture
- Build internal expertise on cutting-edge protein engineering techniques
- Guide prioritization for internal protein generation efforts, balancing between screening and lead characterization
- Build an R&D-to-development pipeline for lead candidates
- Utilize state of the art techniques to drive the development of best-in-class therapeutic candidates
- Stay up to speed on cutting edge research and industry standards for protein therapeutics
Required Qualifications
Preferred Qualifications
Why you might be a good fit
If you're excited to build a platform that combines DNA and protein multiplexing technologies, please apply!
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
