Research Associate, CMC Radiochemistry

Description:

We are seeking an experienced Research Associate, CMC Radiochemistry to join Mariana’s CMC organization, advancing personalized medicine and radiopharmaceuticals.

Illustrative Breadth of Responsibilities:

·       Implement and perform new and/or routine radiochemistry procedures and protocols under the direction of the CMC team

·       Investigate, analyze, and reach preliminary scientific conclusions related to research planning

·       Ensure data results are compiled, analyzed, and presented properly

·       Analyze, develop, interpret, and maintain clear documentation of scientific results

·       Prepare scientific reports for internal reporting purposes

·       Perform independent research and laboratory techniques and participate in experimental research planning

·       Opportunity to engage in early drug product formulation feasibility process development and analytical methodologies

·       Opportunity to learn radiolabeling/ coordination chemistry process, analytical development and troubleshooting with a broad range of radioisotopes, including but not limited to: Lu-177, Ac-225, Zr-89, Cu-64, In-111, Ga-68 and Pb-212

·       Participate in the development and process validation of radiopharmaceutical production procedures for use in preclinical and clinical studies

·       Participate and support CMC process and analytical development, method validation, and reporting activities

·       Support team communications in disseminating the results, which may come in the form of writing reports, presenting at internal meetings

·       Contribute to the organization, safety, and maintenance of the laboratory

Requirements/Skills:

·       A BS degree in Chemistry, Radiochemistry, or related discipline with 0-2 years of Biotech, Pharmaceutical, and/or PET industry experience in relevant biologics and peptides metal chelates chemistry development.

·       Knowledge of GMP is a plus

·       Radiopharmaceutical drug substance and drug product development experience and quality control is a plus

·       Analytical chemistry, specifically HPLC analysis

·       Working with radiopharmaceuticals, with a good understanding of the radiation safety regulations and guidelines, is preferred

·       Proven ability to adhere to good documentation standards and maintain detailed records of all work performed

·       Excellent verbal and written communication skills

Mariana Oncology’s Principles

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·      Execution Excellence

·      Courage of our Convictions