What are the responsibilities and job description for the Technical Research Assistant II Laboratory for Translational Research on Neurodegeneration position at Mass General Brigham?
Site: The McLean Hospital Corporation
At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.
At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.
Job Summary
McLean Hospital is a comprehensive psychiatric hospital committed to providing easy access to superior quality, cost-effective mental health services in the Boston area, Massachusetts and beyond. Since 1811, McLean Hospital has been a world leader in the treatment of mental illness and chemical dependency, research into the cause of mental illness and the training of generations of mental health care providers. McLean's multidisciplinary programs treat a broad range of psychiatric illnesses across the full continuum of care.
We are looking for an RA to help us in our studies of the role of bioenergetics in Alzheimer's disease (AD). Our work is focused on understanding the molecular and cellular mechanisms in AD and particularly how changes in metabolic and bioenergetic cell functions during the aging process contribute to the pathogenesis of AD. We work with fibroblast cell lines and induced pluripotent stem cells (iPSC) that are derived from AD patients and healthy control individuals. The fibroblasts and neural cell populations differentiated from the iPSC lines are analyzed for their molecular and cellular phenotypes and functions with an emphasis on metabolism and bioenergetics.
Working under the general supervision of a Senior Technical Research Assistant, Manager, or Principal Investigator, with assistance of summer interns and junior staff, and following established policies and procedures, the RA will conduct a variety of routine experiments where methodologies are clearly established. They may also calculate, transcribe, and analyze data using basic statistics and may perform literature searches under direction.
PRINCIPAL DUTIES ANDRESPONSIBILITIES: Under general supervision, performs routine experiments, which can be moderate to complex. Experiments may include tissue culture, preparing special materials, performing molecular biology and biochemical assays, immunocytochemistry and fluorescent microscopy, imaging, and computational data analysis.
Qualifications
SKILLS/ABILITIES/COMPETENCIES REQUIRED:
Qualifications
Additional Job Details (if Applicable)
Remote Type
Hybrid
Work Location
115 Mill Street
Scheduled Weekly Hours
40
Employee Type
Regular
Work Shift
Day (United States of America)
EEO Statement:
The McLean Hospital Corporation is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.
At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.
Job Summary
McLean Hospital is a comprehensive psychiatric hospital committed to providing easy access to superior quality, cost-effective mental health services in the Boston area, Massachusetts and beyond. Since 1811, McLean Hospital has been a world leader in the treatment of mental illness and chemical dependency, research into the cause of mental illness and the training of generations of mental health care providers. McLean's multidisciplinary programs treat a broad range of psychiatric illnesses across the full continuum of care.
We are looking for an RA to help us in our studies of the role of bioenergetics in Alzheimer's disease (AD). Our work is focused on understanding the molecular and cellular mechanisms in AD and particularly how changes in metabolic and bioenergetic cell functions during the aging process contribute to the pathogenesis of AD. We work with fibroblast cell lines and induced pluripotent stem cells (iPSC) that are derived from AD patients and healthy control individuals. The fibroblasts and neural cell populations differentiated from the iPSC lines are analyzed for their molecular and cellular phenotypes and functions with an emphasis on metabolism and bioenergetics.
Working under the general supervision of a Senior Technical Research Assistant, Manager, or Principal Investigator, with assistance of summer interns and junior staff, and following established policies and procedures, the RA will conduct a variety of routine experiments where methodologies are clearly established. They may also calculate, transcribe, and analyze data using basic statistics and may perform literature searches under direction.
PRINCIPAL DUTIES ANDRESPONSIBILITIES: Under general supervision, performs routine experiments, which can be moderate to complex. Experiments may include tissue culture, preparing special materials, performing molecular biology and biochemical assays, immunocytochemistry and fluorescent microscopy, imaging, and computational data analysis.
- Maintains long-term tissue cultures of human cell lines and monitors cells for viability and contamination, differentiation of stem cells and gene-engineering using lentivirus vector technologies.
- Record data, summarizes, and analyzes results using basic statistics.
- Prepares laboratory reagents and chemicals. Maintains instruments and equipment.
- Maintains supplies inventory in accordance with departmental procedures.
- Discusses progress of work regularly with supervisor.
- Performs all other duties as assigned.
Qualifications
SKILLS/ABILITIES/COMPETENCIES REQUIRED:
- Basic techniques in cell culture, molecular and cellular biology, and biochemistry, general lab work, and the execution of complex experimental designs.
- High degree of computer literacy.
- Good interpersonal and communication skills.
- Good organizational skills, detail oriented.
- Ability to methodically record data and to analyze data using basic statistics.
- Ability to perform a variety of routine tests and prioritize work.
- Ability to demonstrate professionalism.
Qualifications
- BS or BA in a biological/physical science required.
- Some relevant work experience
- Sound independent judgment and competence in research methodologies.
Additional Job Details (if Applicable)
Remote Type
Hybrid
Work Location
115 Mill Street
Scheduled Weekly Hours
40
Employee Type
Regular
Work Shift
Day (United States of America)
EEO Statement:
The McLean Hospital Corporation is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
