What are the responsibilities and job description for the Senior Scientist, LCMS Peptide Quantitation position at Maxis Clinical Sciences?
Job Description
Job Description
Job Title : Senior Scientist, LCMS Peptide Quantitation
Location : San Francisco, California
Full time Permanent role
This role is in San Francisco headquarters with an expectation of at least 4 days per week in office.
THE OPPORTUNITY
Looking for an enthusiastic Senior Scientist in LCMS Peptide Quantitation accountable for ensuring development and execution of discovery to preclinical peptide quantitative assays. You will be involved in strategic planning and development of assays featuring quantitative measurement of peptides both from in-vitro and in-vivo sources. These assays support the discovery, development and pharmacokinetics of conditionally activated biologics including T-cell engagers and cytokines. You will lead technical collaboration and planning with internal cross-functional teams and represent Company as a subject matter expert in modern peptide quantitation methods using LCMS.
You will report to the Senior Director, Research Oncology.
WHAT YOU'LL DO
- Chromatography and mass spectrometry method development for peptide quantitation in support of discovery, development and pre-clinical studies (PK).
- Generation of workflows using Data Independent-analysis / SWATH; Parallel Reaction Monitoring (or MRMHR); Multiple Reaction Monitoring, as well as Data-dependent analyses for peptide quantitation : applying the optimal use-case for each workflow.
- Perform proteolytic digestion of proteins for LCMS analyses.
- Perform protein immunocapture / affinity purification from biological matrices such as plasma or serum.
- Perform sample cleanup and purification for LCMS.
- Work cross-functionally with members of other departments to complete tasks when required.
- Write development reports, SOPs, and contribute to writing relevant sections in IND submissions to regulatory authorities.
- Manage externally facing interactions and occasionally acting as a subject matter expert for the outsourcing of in-house developed methods (sample analysis and method : transfer, development, and validation oversight).
WHO YOU ARE AND WHAT YOU BRING
Contribute to discovery and development by identifying opportunities and supporting continuous improvement.
Company Description
Maxis Clinical Sciences provides complete Solution for Clinical and Digital Services. Maxis Clinical Sciences has been recognized in the industry for years, and an integrated research competence center. The company provides 24×7 delivery globally, with teams across the world’s 3 largest continents – North America, Europe and Asia. We operates with a problem-solving approach that believes in promoting genuine relationships & steady communication. It works as true clinical and digital competence center and provides services with 200 plus techno-functional, domain experts, each with 12 years of average experience.
Our popular service niches that earned us global accolades are : clinical data management, clinical analytics, patient-centric technology enablement services, statistical analysis and reporting services, data anonymization services, RWD aggregation and curation services etc.
Company Description
Maxis Clinical Sciences provides complete Solution for Clinical and Digital Services. Maxis Clinical Sciences has been recognized in the industry for years, and an integrated research competence center. The company provides 24×7 delivery globally, with teams across the world’s 3 largest continents – North America, Europe and Asia. We operates with a problem-solving approach that believes in promoting genuine relationships & steady communication. It works as true clinical and digital competence center and provides services with 200 plus techno-functional, domain experts, each with 12 years of average experience. Our popular service niches that earned us global accolades are : clinical data management, clinical analytics, patient-centric technology enablement services, statistical analysis and reporting services, data anonymization services, RWD aggregation and curation services etc.
