What are the responsibilities and job description for the Director, Computational Biology position at Maze Therapeutics?
The Position
The Translational Genomics team at Maze Therapeutics is seeking an innovative Director of Computational Biology to play a pivotal role in transforming genetic insights into life-changing therapies . You will lead the development and implementation of strategies to analyze internal and external multi-omics datasets using proprietary computational pipelines. Your work will be central to target validation and understanding how drugs impact biological pathways, helping to shape the future of drug discovery at Maze.
As a key member of our Translational genomics team, you will collaborate across human genetics, functional genomics, data science, biology, and drug discovery groups. You will also build and lead a team of computational biologists to drive innovation and maximize the impact of our therapeutic programs. This position reports to the VP of Translational Genomics and will require you to provide strategic insights and updates to leadership on the progress and outcomes of ongoing projects.
The Impact You’ll Have
- Lead Innovation : Drive Maze's strategy in scientific and technological advancements through the implementation of cutting-edge bioinformatics platforms to accelerate our understanding of biological pathways and genetic effects on human disease.
- Data Analysis : Perform and oversee comprehensive analyses of internal and external multi-omics datasets to accelerate the evaluation and development of therapeutic programs.
- Cross-Functional Collaboration : Partner with Genetics, Functional Genomics, Data Science, and Biology teams to design experiments and seamlessly integrate computational and experimental data.
- Strategic Partnerships : Identify and foster collaborations with contract research organizations and academic institutions to leverage the latest advancements in the multi-omics field.
- Pipeline Development : Design, implement, and execute robust computational pipelines to address complex biological challenges, such as characterizing the molecular impact of disease-associated genetic variants.
As a Director, we also expect our leaders to demonstrate the following Leadership Competencies :
Builds communication channels across Maze for sharing information
Champions partnerships and connections across Maze
Addresses gaps and leverages strengths to get best results
Removes barriers to staff development and empowers them to make their own decisions
What We’re Looking For
About Maze Therapeutics
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $225,000 - $275,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
Salary : $225,000 - $275,000
