What are the responsibilities and job description for the Computational Expertise - Hematopoietic Biology & Malignancy position at MD Anderson Cancer Center?
A Postdoctoral position is available in the Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. This position reports to Dr. Pavan Bachireddy in the Department of Hematopoietic Biology & Malignancy.
We are seeking a talented and highly motivated Postdoctoral Fellow interested in understanding the co-evolutionary interactions between cancer and immune cells in the tumor microenvironment. Our lab uses unbiased, high-throughput technologies to decode the rules of interaction among diverse cell types in the tumor milieu that determine patient outcomes to cancer immunotherapy, primarily in hematologic malignancies (NEJM 2016; Cell 2018; Sci Transl Med 2020; Blood 2021; Cell Reports 2021).
We are especially interested in Fellows with computational or (epi)genomic expertise to develop new molecular tools that capture multi-modal information at single cell resolution, including spatial contexts. Finally, in vitro and in vivo functional genomic screens are critical approaches to validate and extend our findings.
Dr. Bachireddy is also deeply committed to the career growth and success for each member of the laboratory. Such mentorship should be intentional, planned and tailored to each member of the group - thus the laboratory operates with a primary goal of fostering career goals and development. To this end, a mentorship plan will be developed involving a senior faculty member with complementary expertise.
We are looking for an enthusiastic, self-motivated, independent thinker with a tremendous work ethic. The position will require great planning and organizational skills. An ability to work well with others as part of a cohesive team, take initiative, and creatively problem-solve are a must. Because Dr. Bachireddy is also the Scientific Director of the ECLIPSE (Evolution of Cancer, Leukemia, and Immunity Post Stem cell transplant) platform, the fellow will have significant interaction and access to the vast immunogenomic and computational resources of the physically adjacent ECLIPSE platform.
LEARNING OBJECTIVES
The Postdoctoral Fellow will conduct experiments, perform data analysis and prepare manuscripts in addition to attending lab meetings, journal clubs, and research seminars. The Postdoctoral Fellow's primary research focus is on hematologic malignancies that determine patient outcomes to cancer immunotherapy. The Postdoctoral Fellow will train, learn, and study design, data analysis, and manuscript writing.
The fellow will lead work focused on 1) interrogation of factors reversing immune dysfunction; 2) evolutionary modeling of cancer-immune interactions over time and 3) identification of molecular and cellular determinants of successful anti-leukemia outcomes, using multiple cutting-edge technologies as well as standard cell culture and immunologic approaches.
Eligibility Requirements
Individuals with a PhD degree in cancer biology, molecular biology, genomics, genetics, immunology, or related fields. Experiences that are desirable (but not required) include: CRISPR, next-gen sequencing (bulk or single cell genomics), and/or immunology. Candidate should have the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.
POSITION INFORMATION
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000. depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition
08/31/2025
We are seeking a talented and highly motivated Postdoctoral Fellow interested in understanding the co-evolutionary interactions between cancer and immune cells in the tumor microenvironment. Our lab uses unbiased, high-throughput technologies to decode the rules of interaction among diverse cell types in the tumor milieu that determine patient outcomes to cancer immunotherapy, primarily in hematologic malignancies (NEJM 2016; Cell 2018; Sci Transl Med 2020; Blood 2021; Cell Reports 2021).
We are especially interested in Fellows with computational or (epi)genomic expertise to develop new molecular tools that capture multi-modal information at single cell resolution, including spatial contexts. Finally, in vitro and in vivo functional genomic screens are critical approaches to validate and extend our findings.
Dr. Bachireddy is also deeply committed to the career growth and success for each member of the laboratory. Such mentorship should be intentional, planned and tailored to each member of the group - thus the laboratory operates with a primary goal of fostering career goals and development. To this end, a mentorship plan will be developed involving a senior faculty member with complementary expertise.
We are looking for an enthusiastic, self-motivated, independent thinker with a tremendous work ethic. The position will require great planning and organizational skills. An ability to work well with others as part of a cohesive team, take initiative, and creatively problem-solve are a must. Because Dr. Bachireddy is also the Scientific Director of the ECLIPSE (Evolution of Cancer, Leukemia, and Immunity Post Stem cell transplant) platform, the fellow will have significant interaction and access to the vast immunogenomic and computational resources of the physically adjacent ECLIPSE platform.
LEARNING OBJECTIVES
The Postdoctoral Fellow will conduct experiments, perform data analysis and prepare manuscripts in addition to attending lab meetings, journal clubs, and research seminars. The Postdoctoral Fellow's primary research focus is on hematologic malignancies that determine patient outcomes to cancer immunotherapy. The Postdoctoral Fellow will train, learn, and study design, data analysis, and manuscript writing.
The fellow will lead work focused on 1) interrogation of factors reversing immune dysfunction; 2) evolutionary modeling of cancer-immune interactions over time and 3) identification of molecular and cellular determinants of successful anti-leukemia outcomes, using multiple cutting-edge technologies as well as standard cell culture and immunologic approaches.
Eligibility Requirements
Individuals with a PhD degree in cancer biology, molecular biology, genomics, genetics, immunology, or related fields. Experiences that are desirable (but not required) include: CRISPR, next-gen sequencing (bulk or single cell genomics), and/or immunology. Candidate should have the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.
POSITION INFORMATION
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000. depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition
08/31/2025
Salary : $64,000 - $76,000
