What are the responsibilities and job description for the Institute Research Investigator ADME/PK position at MD Anderson Cancer Center?
Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.
The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.
The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation’s leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.
The Institute Research Investigator in the ADME/PK Group will contribute to the advancement of IACS small molecule drug discovery projects by leading ADME studies. The scientist will enable advancement of projects through both leadership and experimental activities. The position requires a highly self-motivated individual, with outstanding organizational and communication skills. The ability to work well under pressure and drive towards individual and team objectives that impact critical timelines is expected. A collaborative attitude is essential for the position.
They will have good communication skills and will regular liaise with other members of the cross-functional project team. This individual will be a key contributor in the identification and optimization of the next generation of cancer therapeutics.
JOB SPECIFIC COMPETENCIES
* Design and perform in vitro ADME assays on drug discovery programs, such as liver microsomal and hepatocytic stability assays, plasma protein binding assay, and MDCK cell permeability assay etc.
* Propose innovative solutions to research project ADME issues and contribute to project goals through laboratory experiments.
* Operate and maintain instruments including LC-MS/MS and liquid automation handling systems such as Biomek FXp.
* Write validation protocols and reports; maintain accurate research records and laboratory notes; Be able to critically analyze and verify data prior to data release; Trouble shoot assay issues.
* Works closely and mentor junior research associate scientists on conducting assays and operating instruments.
* Serve as the ADME/PK representative on project teams; Interact effectively with these cross-functional teams towards the optimization of drug candidates with optimal ADME-PK properties and serve as a point of contact on the programs.
Preferred: Experience in high resolution or triple quadrupole mass spectrometers. Previous experience with in vitro ADME assays or metabolite identification is preferred but not required. Medicinal chemists considering career changes are encouraged to apply.
