Demo

Associate Director - Structural Biology

Menlo Ventures
San Diego, CA Full Time
POSTED ON 1/22/2025
AVAILABLE BEFORE 4/18/2025

Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our San Diego lab seeks a motivated and enthusiastic structural biologist to enhance our expertise in X-ray crystallography, cryo-electron microscopy, and structure based drug design. The successful candidate will collaborate and / or lead multidisciplinary drug discovery projects, manage CRO resources and develop structural biology strategy.Job Responsibilities / What you will do :

  • Develop and implement structural biology strategies for drug discovery programs from target evaluation to candidate nomination
  • Lead and coordinate structural biology research projects, including managing CRO activities
  • Guide protein-small molecule complex structures to support structure-based drug design and platform evolution
  • Collaborate with other drug discovery disciplines (biology, medicinal chemistry, DPMK, software engineers, computational chemists) to drive hypothesis driven decisions and enhance the platform
  • Regularly communicate and engage with project team members and management

Education and Experience Requirements / What you'll bring :

  • PhD in crystallography, cry-EM, biophysics, or relevant structural biology degree with 8 years of industrial drug discovery experience or
  • MS in structural biology with at least 14 years of industrial drug discovery experience
  • Expertise in protein production, purification, X-ray crystallography and cryo-EM
  • Experience across oncology and immunology targets
  • Effective management of external CRO structural biology resources
  • Strong understanding of molecular modeling and computational biology
  • Proficiency in characterizing protein-ligand interactions using biophysical methods
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