What are the responsibilities and job description for the Associate Principal Scientist, Project Representative - Boston Pharmacokinetics, Dynamics, Meta[...] position at Merck Sharp & Dohme?
Job Description
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Research Labs in Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.
The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking, and collaborative Associate Principal Scientist to contribute to our small molecule and peptide drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our research division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular / metabolic, neuroscience, and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional teams through strategic design of discovery testing funnels, generation and interpretation of PK and PK / PD data sets, and through effective communication at both internal meetings and external conferences.
In this exciting position, your primary roles will include :
- Project-team representative and subject matter expert on small molecule and / or peptide-based DMPK activities within the oncology and immunology therapeutic areas
- Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeutics
- Design, implementation, and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK / PD), and safety
- Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA), and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates
Education Minimum Requirement
Experience and Skills (Highly preferred, must have 3 / 4 of listed technical skills) :
Preferred Experience and Skills
Employee Status : Regular
Relocation :
Domestic / International
VISA Sponsorship :
Travel Requirements :
Job Posting End Date :
01 / 17 / 2025
Requisition ID : R316404
J-18808-Ljbffr
