Principal Scientist, Robotics, Translational Sciences and Outsourcing

Job Description

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are seeking a highly motivated Principal Scientist with a strong laboratory automation and strategic business planning skills set to join the Translational Sciences and Outsourcing group at West Point/Spring-House, PA to deliver and execute on laboratory automation (robotic) solutions. The primary role of the successful candidate will be to collaborate translating project team design requirements to successfully execute scientific processes on robotic platforms. Establish standard operating practices and engage in cross function end to end process development with science and IT.

The candidate must have hands-on experience with the design, develop and transfer of automated ADME (absorption, distribution, metabolism and excretion) screening, quantitative measurement and vaccine clinical assays, and is able facilitate the execution of these assays both individually and through team members.

The successful candidate will have a proven track record to develop, optimize and execute scientific processes on robotic platforms. The candidate should be current on state-of-the art technologies and champion the evaluation of new technologies and optimization of processes. Providing leadership and mentorship to junior staff, building relationships with stakeholders, and providing expert technical representation on multidisciplinary teams will be expected.

Education:

• Bachelor Degree in Engineering, Automated Sciences, Computer Science, Biology, Chemistry or equivalent with scientific expertise with laboratory equipment in the development and execution of biological and chemical assays. Bachelors degree with 15 years of experience, Masters with at least 8 years experience and PhD with 5 years experience.

Responsibilities:

• Collaborative leader functioning in a matrix organization: mentor, and inspire scientists at various levels; encourages curiosity in others and challenges the status quo to foster innovation, well-developed decision-making skills that thinks broadly across development programs

• Collaborative leader to liaison between multiple business partners to develop new and current business strategies. Ability to forecast resource needs and constraints to realize these business decisions.

• Design & Operate robotic systems to validate, optimize and execute various therapeutic assays on automation platforms.

• Method development, qualification/validation, trouble-shooting. Support of pre-clinical sample analysis as needed.

• Serve as an subject matter expert on developed assays, providing technical support as needed to internal laboratories working to implement assays.

• Strong communication skills to effectively present results to stakeholders in partner organizations, leadership teams, external scientific meetings, and within a matrix environment.

Qualifications:

• Working knowledge of both ADME screening assay, quantitative pharmacokinetic and vaccine clinical assay protocols (e.g. stability, inhibition, binding, VRNT, Serology) and sample preparation procedures for liquid chromatography mass spectrometry assays (in-vivo and in-vitro.)

• Bioanalytical methods including ligand binding, cell-based neutralization and molecular biology methods to translate assay development to automated systems including LIMS integration

• Working knowledge of GxP regulations and applied use in a laboratory/manufacturing setting.

• Experiences with laboratory automation schedulers such as Cellario, Green Button Go or Momentum. Biosero’s Green Button Go and Thermo Momentum automation is preferred.

• Working knowledge of liquid handlers specifically Beckman and Hamilton.

• Proven capability to independently analyze and interpret experimental data, along with effective skills in presenting and discussing findings within a collaborative, multi-disciplinary team setting.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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• A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
  

Requisition ID:R333127