Research Scientist

Job Title Scientist II

Duration: 6 months with possible extension

Location: Cambridge, MA

Job Description

The Drug Metabolism and Disposition group in QTAS has an open position for a Senior /Research Associate Scientist to perform drug metabolism/metabolite identification studies supporting a series of small molecule drug discovery projects. The selected candidate will be responsible for designing and conducting in vitro metID studies, processing the data, and interpreting MS/MS results. It is a fully drug metabolism laboratory-based role. It would be advantageous for the candidate to have practical hands-on experience performing in vitro and in vivo biotransformation studies, liquid chromatography, mass spectrometry, structure elucidation/identification, fit-for purpose analytical method development including cross-species metabolite profiling.

Responsibilities:

This role is fully lab based. Responsibilities include but not limited to:

• Perform routine soft-spot identification studies and investigational vitro studies to address specific DMPK questions in drug discovery from lead optimization to candidate selection processes
• Develop a series of analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules
• Conduct in-depth analysis of Thermo Exploris 240/ QE LCMS/MS data by using Chemdraw, MassFrontier, Compound Discovere, Webmetabase platform
• Maximize the experience at one of the best places to work environment at AbbVie, with opportunities to network and learn from other professionals in adjacent fields
• Assume responsibility for maintaining laboratory equipment and maintain clear, detailed, and up-to-date experimental records
• Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department
• Conduct other duties as assigned

Required Qualifications:

• Bachelor`s degree in Chemistry, Analytical Chemistry, Biological Sciences and Biochemistry. or related field with at least five years of hands-on, relevant drug metabolism/met ID lab experience working with a mass spectrometer. Master’s degree in Organic Chemistry, Analytical Chemistry, Biochemistry with at least 3 years of experience.
• Hands on Lab experiences performing metabolic stability, CYP inhibition, and metabolite ID studies in liver subcellular fractions and hepatocytes preparing and analyzing samples from in vivo biological matrices using a mass spectrometer (LC-MS/MS)
• Strong consideration will be given to candidates proficient in using and troubleshooting a LC-MS/MS Thermo Exploris 240/ QE instrumentation, and handling Compound Discoverer or Webmetabase is a plus)
• Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing experiments while proactively seeking out senior personnel to discuss potential solutions to problems
• Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges

EEO:

“Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of – Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.”