What are the responsibilities and job description for the Senior Research Associate I/II - In Vivo (6 Month Contract) position at Monte Rosa Therapeutics?
Senior Research Associate I/II – In Vivo (6 Month Contract)
Location: Boston, Massachusetts
Monte Rosa Therapeutics is searching for a Sr Research Associate In Vivo on a 6 month contract to assist to in executing e pivotal proof-of-concept studies in pre-clinical models of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. This person will work primarily in our Animal Care Facility ideally 11-7 to oversee and perform evening and weekend dosing of animals as part of study protocols. This role will have the opportunity to expand their skill set at the lab bench by performing a variety of x-vivo experiments.
Principal Duties And Responsibilities
Perform basic and intermediate veterinary technical tasks in mice independently, including the following:
Administration of selected agents by PO, IP, IV, IM, SC routes.
Blood sampling techniques via multiple routes, including submandibular bleed.
Carry out tissue harvests at later time points based on study requirements.
Preparation of compound formulation for in vivo dosing.
Optimize and perform studies to define target biology in mouse models of inflammation, oncology and immunity for in vivoin vitro and ex vivo applications.
BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.
AALAS certification at the ALAT level is preferred. Uncertified candidates must obtain ALAT certification within 12 – 18 months or demonstrate substantial progress toward certification. LVT qualification is a plus.
Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.
Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques. Experience with surgical techniques is a plus.
Experience in culturing mammalian cell lines is advantageous.
Experience with pharmacodynamics assays of mouse tissue, including Western Blotting, ELISA/Mesoscale and flow cytometry is a plus.
Ability to work flexible hours, including evenings and weekends, as needed.
Strong organizational skills and attention to detail.
Willingness to learn new benchwork skills, including sample processing and cell culture
Interested Candidates may forward CV and Cover Letter letting us know your area of interest please apply online www.monterosatx.com
Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology, and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug.
Location: Boston, Massachusetts
Monte Rosa Therapeutics is searching for a Sr Research Associate In Vivo on a 6 month contract to assist to in executing e pivotal proof-of-concept studies in pre-clinical models of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. This person will work primarily in our Animal Care Facility ideally 11-7 to oversee and perform evening and weekend dosing of animals as part of study protocols. This role will have the opportunity to expand their skill set at the lab bench by performing a variety of x-vivo experiments.
Principal Duties And Responsibilities
Perform basic and intermediate veterinary technical tasks in mice independently, including the following:
Administration of selected agents by PO, IP, IV, IM, SC routes.
Blood sampling techniques via multiple routes, including submandibular bleed.
Carry out tissue harvests at later time points based on study requirements.
Preparation of compound formulation for in vivo dosing.
Optimize and perform studies to define target biology in mouse models of inflammation, oncology and immunity for in vivoin vitro and ex vivo applications.
- Oversee breeding programs, including monitoring litters and documenting outcomes.
- Assist with cage changes and husbandry tasks as needed.
- Perform evening and weekend dosing of animals as part of study protocols.
- Conduct health checks to ensure animal welfare and identify any concerns.
- Carry out tissue harvests at later time points based on study requirements.
- Prepare and perform formulations for dosing studies.
- Oversee breeding programs, including monitoring litters and documenting outcomes.
- Assist with cage changes and husbandry tasks as needed. Processing time sensitive biological samples, collected earlier in the day.
- Perform cell culture work to support in vitro studies and downstream analysis
BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.
AALAS certification at the ALAT level is preferred. Uncertified candidates must obtain ALAT certification within 12 – 18 months or demonstrate substantial progress toward certification. LVT qualification is a plus.
Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.
Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques. Experience with surgical techniques is a plus.
Experience in culturing mammalian cell lines is advantageous.
Experience with pharmacodynamics assays of mouse tissue, including Western Blotting, ELISA/Mesoscale and flow cytometry is a plus.
Ability to work flexible hours, including evenings and weekends, as needed.
Strong organizational skills and attention to detail.
Willingness to learn new benchwork skills, including sample processing and cell culture
Interested Candidates may forward CV and Cover Letter letting us know your area of interest please apply online www.monterosatx.com
Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology, and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug.
