Associate Director

Mosaic Biosciences is a discovery and preclinical development company that partners with biopharmaceutical companies to discover novel protein and antibody therapeutics. Our experienced and dedicated research teams collaborate with our partners to design, manage, and execute research programs to rapidly advance clinical candidates, starting at any point from early discovery into preclinical development. We are seeking a dynamic and experienced Director of Business Development to drive our business growth through commercial development and sales team management.

Position Overview:

We are seeking an experienced and motivated Associate Director to join our growing Antibody Discovery & Optimization (ADO) team. In this senior-level role, you will report to and partner with the Head of ADO to lead the strategic design and execution of workflows to identify and validate therapeutic antibodies. You will also contribute to expanding our capabilities, including library design and optimization methods using our in vitro display platforms. This role involves supervising and mentoring junior team members while collaborating across cross-functional teams to drive innovation, advance research objectives, and uphold high standards of data integrity and ethical compliance.

Key Responsibilities:

• Work with the Head of ADO to provide leadership and oversee day-to-day operations of Mosaic’s Antibody Discovery and Optimization team
• Design naïve and immune phage/yeast antibody display libraries
• Develop and implement new technologies and methodologies for in vitro antibody discovery platforms, including immune repertoire transfer into display platforms.
• Design, execute, and analyze antibody discovery and optimization campaigns, including NGS analysis and triage of hits from campaigns.
• Provide leadership and mentorship to junior team members, enhancing cross-functional capabilities between in vitro and in vivo antibody discovery workflows
• Work collaboratively across functional teams to support consultation and troubleshooting efforts and maintain project deadlines
  
  

Qualifications:

• PhD in Biological/Chemical Engineering, Molecular Biology, Biochemistry, Immunology or related discipline, with 8 years of industry experience
• Demonstrated expertise and hands on experience with in vitro antibody display systems (yeast, phage, mammalian, and/or nucleic acid display)
• Expertise in antibody library design including naïve, structure guided, optimization (affinity, specificity, developability), and humanization
• Experience with bioinformatics analysis and NGS approaches
• Proficiency with tissue harvesting, PBMC isolation, B-cell FACS sorting of immune repertoires is a plus
• A track record of mentoring and managing junior team members, fostering a collaborative and productive work environment
• Effective time and resource management skills and enthusiasm for working in a team environment
• Ability to work in a dynamic environment with multiple functional groups and external partners with diverse antibody discovery and optimization needs
  
  

Location: This is a full-time position in Boulder, CO with in-person work in our labs.

Compensation Range: $135,000- $160,000

As a member of our team, you will be eligible for comprehensive, competitive, flexible benefits that include health and dental insurance, disability and life insurance, 401k with company match, and bonus opportunities based on company success.

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