Post Doctoral

Job Description

Title : TR05 Postdoctoral Fellow

Salary : $73,588 total ($30,000 from Zhongshan Hospital, Fudan University)

Department : Medicine / Nephrology

Physical work location (must be proper street address) : 1468 Madison Avenue, Annenberg 23-16, New York, NY 10029

Name PI or Supervisor : John Cijiang He, MD, PhD

Web link to Lab : https : / / labs.icahn.mssm.edu / helab / meet-the-team /

Web link to Department : https : / / icahn.mssm.edu / about / departments / medicine / nephrology

Administrative Contact : Irene Beaulieu; email : Irene.Beaulieu@mssm.edu

Responsibilities

Diabetic kidney disease is the number one cause of kidney failure in the USA as well as in the world. Its underlined pathogenesis remains unclear and the treatment is limited. We have been using systems biology approach to study its pathogenesis in order to identify potential new drug targets to treat this disease. Recently, we identified LRG1 as a key molecule involving in the pathogenesis of diabetic kidney disease. The current project will focus on the discovery of LRG1 inhibitors as potential new therapy for diabetic kidney disease. We will use in vitro assays and in vivo animal models to confirm the critical role of LRG1 in diabetic kidney disease and screen LRG1 inhibitors as novel therapy for diabetic kidney disease.

Technical Duties (include any protocols) :

• We will validate cell-specific effects of LRG1 in the pathogenesis of diabetic kidney disease by using cell-specific knockout mice and single cell analysis.
• We will perform in vitro cell cultures of glomerular endothelial cells and tubular cells to screen different LRG1 inhibitors.
• We have validate the effects of LRG1 inhibitors in vivo in the animal models of diabetic kidney disease.
• Techniques include cell culture, western blot, qPCR, genotyping of mice, mouse breading, kidney histology analysis, immunostaining, determination of urine albumin and renal function.

Qualifications

Educational and other Requirements for the position : Postdoc should have medical training (MD equivalent) or basic science training and is familiar with kidney disease pathogenesis (Nephrology training).

Experience Required : Candidate shouldhave basic training in medical research and know how to perform basic bench works and animal studies.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 036 - Renal MSH - ISM, Icahn School of Medicine

EOE Minorities / Women / Disabled / Veterans

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.?

About Us

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About the Mount Sinai Health System :

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked : No. 1 in Geriatrics and top 20 in Cardiology / Heart Surgery, Diabetes / Endocrinology, Gastroenterology / GI Surgery, Neurology / Neurosurgery, Orthopedics, Pulmonology / Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism."

EOE Minorities / Women / Disabled / Veterans

Salary : $30,000 - $73,588