Senior Scientist- Immunology and Immunotherapy

Job Description

The Gnjatic Laboratory at Mount Sinai is seeking a highly motivated Senior Scientist with expertise in spatial pathology, multiplex immunohistochemistry, and computational analysis of tissue-based data. This is an exciting opportunity to work on cutting-edge technologies such as Visium, Visium HD, Codex, Orion, and CosMX, focusing on clinical trial samples to advance biomarker discovery and immunotherapy research.

The candidate will design and execute experiments, analyze complex spatial data, and collaborate closely with computational scientists and immunologists to uncover clinically relevant insights. This role offers an excellent environment for scientific growth, publication, and leadership in a highly collaborative research setting.

Responsibilities

• Lead research projects in multiplex immunohistochemistry and spatial transcriptomics, characterizing immune infiltration in various tissues (e.g., tumors, inflammatory lesions).
• Develop and validate novel tissue-based assays, ensuring robustness and reproducibility of results.
• Oversee and innovate multiplex immunohistochemical platforms, integrating advanced technologies like MICSSS, Visium, Codex, Orion, and CosMX.
• Analyze spatial and single-cell level data, utilizing computational tools for cell segmentation, tissue morphology, and immune profiling.
• Generate and interpret high-dimensional datasets, including immune cell density, spatial distribution, and proximity to tumor regions.
• Collaborate with computational biologists and clinical researchers, sharing findings and developing integrated pipelines for biomarker discovery.
• Present research at internal and external meetings, contribute to manuscripts and grant proposals, and engage in high-impact publications.

Why Join Us?

We are looking for a passionate and driven scientist eager to push the boundaries of spatial pathology and immuno-oncology. If you're excited about working at the intersection of technology, pathology, and translational medicine, we encourage you to apply!

Qualifications

About Us

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by :

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

About the Mount Sinai Health System :

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked : No. 1 in Geriatrics and top 20 in Cardiology / Heart Surgery, Diabetes / Endocrinology, Gastroenterology / GI Surgery, Neurology / Neurosurgery, Orthopedics, Pulmonology / Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism."

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