What are the responsibilities and job description for the Director Drug Substance External Manufacturing position at Mural Oncology?

Mural Oncology is a clinical-stage immuno-oncology company leveraging its novel protein engineering platform to develop cytokine-based immunotherapies for the treatment of cancer. By combining our expertise in cytokine biology and immune cell modulation with our protein engineering platform, we are developing medicines to deliver meaningful and clinical benefits to people living with cancer. Our mission is to broaden the potential, and reach, of cytokine-based immunotherapies to improve the lives of patients.

Detailed Description :

Mural's Director of Drug Substance External Manufacturing, Supplier Relationship Management (SRM) plays a critical role in enhancing the company's supply chain efficiency and fostering mutually beneficial partnerships with our key suppliers. The role of Drug Substance SRM requires a strategic thinker who will work closely with suppliers to enable strong performance, mitigate risks, foster collaboration and drive value creation. As the main point of contact for supplier relations, the SRM negotiates contracts, ensures supplier compliance and monitors performance to meet both short-term operational needs and long-term organizational strategic objectives. Effective interpersonal, analytical, and negotiation skills are essential, as the SRM seeks to cultivate trust, manage risks, and drive continuous improvement within the supply chain.

Job Responsibilities :

Support the continued development and implementation of the External Manufacturing operating model and business processes across the external network for Mural.

Act as the manufacturing & business relationship manager for designated Suppliers developing mutually beneficial relationships and accountable to deliver high quality, reliable and efficient supply on time and in full.

Directly responsible for batch execution, testing, and release

Manage KPI's, scorecards, and provide management oversight for the external network.

Lead Business Review Meetings with key Suppliers along with other appropriate periodic engagement to manage performance and the business relationship

Identify, implement and monitor continuous improvement initiatives & performance measures within the external network.

Implement and maintain Risk Assessment and Risk Management tools and processes to continually evaluate Supplier risk profiles. Establish remediation strategies / plans to reduce risk and improve supply chain robustness.

Monitor Supplier contracts for compliance with contractual terms.

Work with internal process development group to tech transfer new processes into CMOs for GMP manufacture.

Own, lead and manage the contracting process for assigned Development and Commercial activities with external Suppliers (CMOs, vendors etc.) associated with Mural's products.

Partner with Legal, Finance, Process Development, Quality, External Operations and other SME functions across the internal network to deliver assigned contracts aligned with business goals.

Support the development & implementation of sustainable & scalable management systems and business processes within the contracting space.

Support the preparation and management of the External Operations & Supply Chain budget.

Collaborate with internal stakeholders to ensure alignment and delivery of mutual goals.

Ensure personnel assigned to your area of responsibility are appropriately trained commensurate with their roles & responsibilities.

Qualifications :

Bachelor's degree in Life Sciences, Business or a related area is required, and 8 years relevant work experience

Experience in life sciences or related industry preferred

Minimum 4 years' of contract negotiation, contract management, direct materials category management, supplier relationship management experience.

Strong interpersonal skills, business acumen and a depth of knowledge of core aspects of the business are required to establish and maintain credibility with internal stakeholders and representatives of external suppliers at appropriate levels including senior management

General knowledge of and experience working in a GMP environment.

Awareness of CFR's as they apply to pharmaceutical industry

Experience of collaboration and achieving results across levels, functions, business units, companies and geographies in a matrixed environment an advantage

Excellent communication, influencing, collaboration and technical writing skills

Ability to work independently and manage ambiguity, strong problem-solving skills

Travel - domestic and international - expected to be in the region of 25%.

Remote work position based in Waltham, MA

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Director Drug Substance External Manufacturing

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